24 November 2015
Vol 8, Issue 404

About The Cover

Cover image expansion

Online Cover Depression is a major health issue that can be difficult to treat. This week features a Research Article that shows how the epigenetic effects of some antidepressants are mediated by a swap in the interaction of the kinase CDK5 with two related protein chaperones. Of translational importance, the effects of the antidepressant can be detected in cells from the patient's blood, suggesting a simple blood test may enable personalized treatment. [Image: Stock photo: Alamy DTAWHA]