20 March 2018
Vol 11, Issue 522

About The Cover

Cover image expansion

Online Cover This week features two studies that identified pathological mechanisms of amyloid-β in mouse models of Alzheimer's disease. The issue includes a Research Article that describes how amyloid-β–induced calcium signaling in neurons suppresses the synapse-supporting activity of the prolyl isomerase Pin1 and a Research Article that shows how amyloid-β–induced S-nitrosylation of the protein GAPDH mediates the acetylation and toxic aggregation of tau in neurons. The studies further identified potential opportunities for repurposing drugs to treat patients with Alzheimer's disease. The image depicts dementia as an elderly person gazing at an old photograph. [Image:]