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In the Current Issue 17 November 2009 (Issue 97)

Pyruvate kinase M2 in tumor
metabolism

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Information for Authors

Featured Connections Map:
G Protein Regulation of Disease Resistance During Infection of Rice with Rice Blast Fungus

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Research Articles

Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth: Taro Hitosugi, Sumin Kang, Matthew G. Vander Heiden, Tae-Wook Chung, Shannon Elf, Katherine Lythgoe, Shaozhong Dong, Sagar Lonial, Xu Wang, Georgia Z. Chen, Jianxin Xie, Ting-Lei Gu, Roberto D. Polakiewicz, Johannes L. Roesel, Titus J. Boggon, Fadlo R. Khuri, D. Gary Gilliland, Lewis C. Cantley, Jonathan Kaufman, and Jing Chen
Editor's Summary | Abstract | Full Text | PDF | Supplementary Materials

Trypanosoma cruzi Targets Akt in Host Cells as an Intracellular Antiapoptotic Strategy: Marina V. Chuenkova and Mercio PereiraPerrin
Editor's Summary | Abstract | Full Text | PDF | Supplementary Materials

Perspectives

PKM2 Tyrosine Phosphorylation and Glutamine Metabolism Signal a Different View of the Warburg Effect: Chi V. Dang
Abstract | Full Text | PDF

Acetylation Goes Global: The Emergence of Acetylation Biology: Kristi L. Norris, Joo-Yong Lee, and Tso-Pang Yao
Abstract | Full Text | PDF

Glossary

Discover what TRPA, GJIC, and miR mean in the world of signaling.: New Terms | Search and Browse the Glossary

Editors' Choice

Ensuring Efficient Eating: L. Mukundan et al., Nat. Med. 15, 1266-1272 (2009).
K. B. Elkon, Nat. Med. 15, 1246-1248 (2009).; Read this Summary | Read all Summaries

In Literature

What's Hot: Read this highly accessed article published recently in a previous issue: MSK2 Inhibits p53 Activity in the Absence of Stress Abstract | Full Text
Virtual Journal: Check out this article, just added to the Virtual Journal: Persistence of an atherogenic lipid profile after treatment of acute infection with brucella Abstract | Full Text | Search and browse the Virtual Journal
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In Community

Events, Meeting Reports, and Presentations: Check out the calendar, read highlights, and view presentations of cell signaling meetings and conferences.
Directory: Featured person: Jen Sheen. Find collaborators and people with shared research interests—join the Signaling community and add your information to the Directory!
Forums: Share highlights from signaling meetings, read the announcement about award-winning talks in the Meeting Highlights.
E-Letters: Featured E-Letter: Paradigm Shift. Find out how to submit a comment to make Science Signaling a rich community by contributing your knowledge. For example, share your experiences with a method described in a Protocol; tell other teachers how you used Teaching Resources; alert the community to research related to those highlighted in Editors' Choice; comment on or ask the authors about their articles.

In Resources

Teaching Resources: More than 50 different resources provide information for course planning, lecture notes, slides, and animations.
Glossary: Find out what those acronyms and abbreviations mean. Browse or search the glossary of cell signaling terms. Look at the list of the most recently added terms.
Podcasts: Tune-in for a portable and understandable summary of selected cell signaling research. Check out each episode of the Science Signaling Podcast.
ST NetWatch: Featured in Protein Databases: PHOSIDA: Phosphorylation Site Database. Explore the sites selected by the editors or submit your favorite signal transduction Web site.
Funding Sources: Check out the opportunities for funding cell signaling research and training.
Jobs: Search or browse employment opportunities related to signal transduction in Science Careers.

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