Contents

24 April 2018
Vol 11, Issue 527

About The Cover

Cover image expansion

Online Cover This week features two studies on the mechanisms that regulate the differentiation and maintenance of beige fat, an inducible form of adipose tissue that burns energy as heat. The issue includes a Research Article (see also the associated Focus) that describes how transient inflammation in white adipose tissue triggers cross-talk between the Jak and TGF-β signaling that promotes beige adipocyte differentiation. The issue also includes a Research Article (see also the associated Focus) that reveals how PKA-mediated phosphorylation of Parkin induced by β3-adrenergic receptor signaling prevents the autophagic clearance of mitochondria that reverses browning of white adipose tissue. The image shows a heat map of an adult male, highlighting the potential locations of thermogenically active tissues such as beige fat. [Image: Valery Lisin/shutterstock.com]