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In the Current Issue 15 May 2012 (Issue 224)

Cell screening in miniature

Cell screening in miniature

Associate Editor Position


Research Resource

MicroSCALE Screening Reveals Genetic Modifiers of Therapeutic Response in Melanoma
Kris C. Wood, David J. Konieczkowski, Cory M. Johannessen, Jesse S. Boehm, Pablo Tamayo, Olga B. Botvinnik, Jill P. Mesirov, William C. Hahn, David E. Root, Levi A. Garraway, and David M. Sabatini
Editor's Summary  |  Abstract  |  Full Text  |  PDF  |  Supplementary Materials

Perspectives

The Structure of the Full-Length Tetrameric PKA Regulatory RIIβ Complex Reveals the Mechanism of Allosteric PKA Activation
Jonathan M. Elkins and Stefan Knapp
Abstract  |  Full Text  |  PDF

The Structural Basis of DKK-Mediated Inhibition of Wnt/LRP Signaling
Ju Bao, Jie J. Zheng, and Dianqing Wu
Abstract  |  Full Text  |  PDF

Presentation

Roles of GRK2 in Cell Signaling Beyond GPCR Desensitization: GRK2-HDAC6 Interaction Modulates Cell Spreading and Motility
Petronila Penela, Vanesa Lafarga, Olga Tapia, Verónica Rivas, Laura Nogués, Elisa Lucas, Rocío Vila-Bedmar, Cristina Murga, and Federico Mayor Jr.
Abstract  |  Full Text  |  PDF  |  Slideshow

Glossary

Find out what DSP, K2P, and TAPI mean in the world of cell signaling.
New Terms  |  Search and Browse the Glossary

Editors' Choice

A Coactivator Divided
C. Chauhan et al., Development 139, 1997–2008 (2012).
Read this Summary  |  Read all Summaries

In Literature

What's Hot
Read this highly accessed article published recently in a previous issue:
Regulation of the EGF Transcriptional Response by Endocytic Sorting
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Differential Diffusivity of Nodal and Lefty Underlies a Reaction-Diffusion Patterning System
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In Community

Events, Meeting Reports, and Presentations
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Directory
Featured person: Martin Blackstein. Find collaborators and people with shared research interests—join the Signaling community and add your information to the Directory!
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In Resources

Teaching Resources
Featuring the course "Systems Biology—Biomedical Modeling," explore this and other materials for teachers.
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ST NetWatch
Featured in Bioinformatics Resources: Plant Metabolic Network (PMN). Explore the sites selected by the editors or submit your favorite signal transduction Web site.
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