Original Research: Call for Papers

• Scope
• Review Process
• Article Format
• Electronic Submission

Scope

Science Signaling will publish leading research papers related to the broad topic of signal transduction. Appropriate topics include any analysis of the mechanisms by which cellular functions are regulated in response to external or internal cues. The subject matter will thus cross the boundaries of traditional research areas such as Cancer Biology, Cell Cycle, Cell Biology, Development, Immunology, Microbiology, Molecular Biology, Immunology, Neuroscience, Physiology and Medicine, Pharmacology, and Plant Biology. In particular, Science Signaling will provide a high-profile venue for key research papers in the rapidly expanding areas of signaling networks, systems biology, synthetic biology, computation and modeling of regulatory pathways, and drug discovery.

Review Process

The review process for papers submitted directly to Science Signaling will be highly selective. The number of papers published will be limited to approximately 150 per year. Papers will be selected for publication in Science Signaling on the basis of their importance and broad interest to scientists engaged in the general area of cellular regulation as determined by the editors in consultation with the Board of Reviewing Editors (names to be posted soon) and in-depth reviewers of papers. Acceptable papers should substantially refine current understanding of important signaling processes. Priority will be given to those papers that the reviewers and editors determine to provide new concepts and new understanding of biological signal transduction and that are likely to find application multiple biological systems or in a diverse range of investigations. Papers on mathematical modeling of signaling pathways that are closely aligned with experimental analysis and that use models to generate predictions that are tested experimentally will be favored. Papers describing further examples of known principles of biological signal transduction will be less favorably evaluated.

Whereas Science seeks to present papers of particularly broad interest across the greater scientific community, Science Signaling will seek out papers that have strong interest and broad impact in the more limited context of understanding mechanisms of cellular regulation.

Papers submitted to Science, but not accepted for publication may, in some cases, be eligible for publication in Science Signaling. Two scenarios are likely to be most common: In certain cases, reviewers are satisfied that a paper's conclusions are adequately supported by the data presented, but the general interest of the findings is not found to be sufficient to justify publication in Science. In such a case, the authors will be offered the opportunity for publication in Science Signaling, with further review required in those cases where reviewers require that additional experiments are added during revision. Conversely, some papers provide provocative new concepts, but are not thought to be sufficiently persuasive to be appropriate for a general-interest journal like Science. In this case again, reviewers and editors may find an appropriately worded version of the paper to be acceptable for publication in Science Signaling.

Article Format

Research Articles will average 8 to 10 pages in length, should include an abstract and be structured as follow: Introduction, Results, Discussion and Materials and Methods. Supplementary Material will be permitted but should be limited to information that is not essential to the understanding and evaluation of the research presented in the paper. Please see the Information for Authors for more details.

Electronic Submission

Primary research articles may be submitted online www.submit2SciSignal.org.

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