Original Research: Call for Papers
Instructions for Authors
Instructions for preparing Research Articles for initial submission [PDF]
Word Template for Research Submissions [Template]
Instructions for preparing Research Articles at the revision stage [PDF]
Online submission site for new submissions www.submit2SciSignal.org
Published Research Articles can be short (4 to 5 pages with 2 to 4 figures) or long (8 to 10 pages with 5 to 7 figures). Both short and long Research Articles include an Abstract and should be structured as follows: Introduction, Results, Discussion, and Materials and Methods. Supplementary Materials are permitted but should be limited to information that is not essential to the understanding and evaluation of the research presented in the paper. For a short format article, the manuscript may be 3000 to 5000 words with 2 to 4 figures. For longer format articles, a general guideline is 5 to 7 figures and 5000 to 7000 words. Authors should refer to the Information for Authors for general information about manuscript preparation and the journal's policies. Submitted manuscripts should be as complete as possible and the editors will assist authors in shortening manuscripts if accepted.
As of September 2008, Science Signaling publishes leading research papers related to the broad topic of signal transduction. Appropriate topics include any analysis of the mechanisms by which cellular functions are regulated in response to external or internal cues in both eukaryotic and prokaryotic cells. The subject matter thus crosses the boundaries of traditional research areas, such as Cancer Biology, Cell Cycle Regulation, Cell Biology, Biochemistry, Development, Microbiology, Molecular Biology, Immunology, Neuroscience, Physiology and Medicine, Pharmacology, and Plant Biology. Papers should substantially refine current understanding of important signaling processes with priority given to those papers that provide new concepts and new understanding of biological signal transduction and that are likely to find application in multiple biological systems or in a diverse range of investigations.
The goal is to publish papers that expand our knowledge of important signaling processes and mechanisms of cellular regulation. The target audience is the general cell signaling community, so instead of fitting papers into "immunology" or "neuroscience" pigeon holes, for example, we see the the Research Articles as immunology- or neuroscience-based signaling papers that are of interest not only to the immunologist or neuroscientist, but also to the broad signaling community. Because the audience is broad and diverse, papers should be presented so that they are accessible to those outside the direct area of study.
Given the increasing blurred lines between the classical scientific disciplines, there is a need for a journal that can convey important findings between research groups with different backgrounds. Science Signaling seeks to fulfill this role, bridging the disciplines spanned by the cell signaling research community.
The review process for papers submitted directly to Science Signaling is highly selective. Papers are selected for publication in Science Signaling on the basis of their importance and broad interest to scientists engaged in the general area of cellular regulation as determined by the editors in consultation with the Board of Reviewing Editors and in-depth reviewers of papers. Papers describing further examples of known principles of biological signal transduction will be less favorably evaluated. For papers describing mathematical modeling of signaling pathways, those that are closely aligned with experimental analysis and that use models to generate predictions that are tested experimentally will be favored.
Whereas Science seeks to present papers of particularly broad interest across the greater scientific community, Science Signaling will seek out papers that have strong interest and broad impact in the more limited context of understanding mechanisms of cellular regulation.
Papers submitted to Science, but not accepted for publication may, in some cases, be eligible for publication in Science Signaling.
Research Articles are accompanied by short summaries written by the Science Signaling staff editors. These can be accessed by either navigating to the Editors' Summaries section of the Literature part of the site or by choosing the Editor's Summary view from the article.
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882