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To give readers and potential authors a flavor of the kinds of papers published by Science Signaling, the editors have selected the following influential articles and made them freely available.

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2012: Research Articles

Wnt/β-Catenin Signaling and AXIN1 Regulate Apoptosis Triggered by Inhibition of the Mutant Kinase BRAFV600E in Human Melanoma
Travis L. Biechele, Rima M. Kulikauskas, Rachel A. Toroni, Olivia M. Lucero, Reyna D. Swift, Richard G. James, Nick C. Robin, David W. Dawson, Randall T. Moon, and Andy J. Chien
GPRC5B Activates Obesity-Associated Inflammatory Signaling in Adipocytes
Yeon-Jeong Kim, Takamitsu Sano, Takuji Nabetani, Yoshimi Asano, and Yoshio Hirabayashi

2011: Research Articles

p38α Signaling Induces Anoikis and Lumen Formation During Mammary Morphogenesis
Huei-Chi Wen, Alvaro Avivar-Valderas, Maria Soledad Sosa, Nomeda Girnius, Eduardo F. Farias, Roger J. Davis, and Julio A. Aguirre-Ghiso
Identification of a Lysosomal Pathway That Modulates Glucocorticoid Signaling and the Inflammatory Response
Yuanzheng He, Yong Xu, Chenghai Zhang, Xiang Gao, Karl J. Dykema, Katie R. Martin, Jiyuan Ke, Eric A. Hudson, Sok Kean Khoo, James H. Resau, Arthur S. Alberts, Jeffrey P. MacKeigan, Kyle A. Furge, and H. Eric Xu

2010: Research Articles

TREM2- and DAP12-Dependent Activation of PI3K Requires DAP10 and Is Inhibited by SHIP1
Qisheng Peng, Shikha Malhotra, James A. Torchia, William G. Kerr, K. Mark Coggeshall, and Mary Beth Humphrey
DNMT1 Stability Is Regulated by Proteins Coordinating Deubiquitination and Acetylation-Driven Ubiquitination
Zhanwen Du, Jing Song, Yong Wang, Yiqing Zhao, Kishore Guda, Shuming Yang, Hung-Ying Kao, Yan Xu, Joseph Willis, Sanford D. Markowitz, David Sedwick, Robert M. Ewing, and Zhenghe Wang

2009: Research Articles

Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth
Taro Hitosugi, Sumin Kang, Matthew G. Vander Heiden, Tae-Wook Chung, Shannon Elf, Katherine Lythgoe, Shaozhong Dong, Sagar Lonial, Xu Wang, Georgia Z. Chen, Jianxin Xie, Ting-Lei Gu, Roberto D. Polakiewicz, Johannes L. Roesel, Titus J. Boggon, Fadlo R. Khuri, D. Gary Gilliland, Lewis C. Cantley, Jonathan Kaufman, and Jing Chen
STIM2 Regulates Capacitive Ca2+ Entry in Neurons and Plays a Key Role in Hypoxic Neuronal Cell Death
Alejandro Berna-Erro, Attila Braun, Robert Kraft, Christoph Kleinschnitz, Michael K. Schuhmann, David Stegner, Thomas Wultsch, Jens Eilers, Sven G. Meuth, Guido Stoll, and Bernhard Nieswandt

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882