Notch Signaling in Osteoblasts
Ernesto Canalis*
Department of Research, Saint Francis Hospital and Medical Center, 114 Woodland Street, Hartford, CT 06105, USA, and University of Connecticut School of Medicine, Farmington, CT 06030, USA.
Abstract:
Bone remodeling is the result of the coordinated activity of osteoblasts, which form new matrix, and osteoclasts, which resorb bone. Notch proteins are single-pass transmembrane receptors that determine cell fate. Recent gain-of-function and loss-of-function experiments reveal a suppressive effect of Notch in osteoblast and osteoclast differentiation in development and in the postnatal bone, which establishes a role for Notch signaling in bone remodeling.
*Corresponding author. E-mail, ecanalis{at}stfranciscare.org
