Steering in Quadruplet: The Complex Signaling Pathways Directing Chemotaxis
Erin C. Rericha1 and
Carole A. Parent2*
1Institute for Research in Electronics and Applied Physics, University of Maryland, College Park, MD 20742, USA.
2Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Abstract:
Studies in the social amoeba Dictyostelium discoideum reveal that signaling cascades coordinating chemotactic directional sensing and migration are complex, with redundant pathways emerging as cells differentiate. Lack of accumulation of the leading-edge marker phosphatidylinositol-3,4,5-trisphosphate can be compensated by a pathway containing phospholipase A2 (PLA2) in early developed cells and guanylyl cyclase (GC) in later developed, polarized cells. Because numerous signaling networks operational during Dictyostelium chemotaxis are conserved in mammalian cells, PLA2 and GC pathways may also be effective in higher eukaryotes, providing avenues for future research.
*Corresponding author. E-mail, parentc{at}mail.nih.gov
