An All-Purpose Tool for Axon Guidance

Leslayann C. Schecterson and Mark Bothwell^*

Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195–7290, USA.

Abstract: The functions of the 75-kilodalton neurotrophin receptor p75^NTR have remained enigmatic despite nearly three decades of study. Recent studies reveal that p75^NTR is a versatile co-receptor that controls signaling by receptors for multiple ligands that provide repellant guidance cues to developing axons.

* Corresponding author. E-mail, markbothwell{at}hotmail.com

The editors suggest the following Related Resources on Science sites:

In Science Signaling

EDITORS' CHOICE
Cell Biology
New Nrps Nexus

Annalisa M. VanHook (22 November 2011)
Sci. Signal. 4 (200), ec325. [DOI: 10.1126/scisignal.4200ec325]
 |  Abstract »

EDITORS' CHOICE
Neuroscience
TrkB or Not TrkB?

L. Bryan Ray (14 September 2010)
Sci. Signal. 3 (139), ec280. [DOI: 10.1126/scisignal.3139ec280]
 |  Abstract »

EDITORS' CHOICE
Neuroscience
Synapse Specification Goes Retro

Wei Wong (17 August 2010)
Sci. Signal. 3 (135), ec248. [DOI: 10.1126/scisignal.3135ec248]
 |  Abstract »

EDITORS' CHOICE
Receptors
Notch-like Neurotrophin Receptor

L. Bryan Ray (23 February 2010)
Sci. Signal. 3 (110), ec63. [DOI: 10.1126/scisignal.3110ec63]
 |  Abstract »

EDITORS' CHOICE
Neuroscience
Signaling Stop from the Inside

Nancy R. Gough (2 February 2010)
Sci. Signal. 3 (107), ec36. [DOI: 10.1126/scisignal.3107ec36]
 |  Abstract »

EDITORS' CHOICE
Neuroscience
Transcription Factor for p75^NTR

Nancy R. Gough (10 February 2009)
Sci. Signal. 2 (57), ec47. [DOI: 10.1126/scisignal.257ec47]
 |  Abstract »

PERSPECTIVES
STKE Perspectives
From Cell Death to Neuronal Regeneration, Effects of the p75 Neurotrophin Receptor Depend on Interactions with Partner Subunits

Christine Bandtlow and Georg Dechant (1 June 2004)
Sci. STKE 2004 (235), pe24. [DOI: 10.1126/stke.2352004pe24]
 |  Abstract »  |  Full Text »  |  PDF »