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Sci. Signal., 25 November 2008
Vol. 1, Issue 47, p. pe50
An All-Purpose Tool for Axon Guidance
Leslayann C. Schecterson and
Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195–7290, USA.
The functions of the 75-kilodalton neurotrophin receptor p75NTR have remained enigmatic despite nearly three decades of study. Recent studies reveal that p75NTR is a versatile co-receptor that controls signaling by receptors for multiple ligands that provide repellant guidance cues to developing axons.