Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 25 November 2008
Vol. 1, Issue 47, p. pe50
[DOI: 10.1126/scisignal.147pe50]

PERSPECTIVES

An All-Purpose Tool for Axon Guidance

Leslayann C. Schecterson and Mark Bothwell*

Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195–7290, USA.

Abstract: The functions of the 75-kilodalton neurotrophin receptor p75NTR have remained enigmatic despite nearly three decades of study. Recent studies reveal that p75NTR is a versatile co-receptor that controls signaling by receptors for multiple ligands that provide repellant guidance cues to developing axons.

* Corresponding author. E-mail, markbothwell{at}hotmail.com

Citation: L. C. Schecterson, M. Bothwell, An All-Purpose Tool for Axon Guidance. Sci. Signal. 1, pe50 (2008).

Read the Full Text



To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882