Sci. Signal., 19 February 2008
[DOI: 10.1126/stke.17tr1]
TEACHING RESOURCES
Quantitative Models of Mammalian Cell Signaling Pathways
Ravi Iyengar*
Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.
Abstract:
This teaching resource provides lecture notes and slides for a class on mathematical modeling of mammalian signaling pathways. This lecture was part of the course "Cell Signaling Systems: A Course for Graduate Students" and focused on quantitative modeling. The lecture describes how different types of mathematical representations are applied to different signaling systems to provide insight into how a signaling system controls cell behavior. The development of an ordinary differential equation–based model for a bistable switch and the predictions that can be obtained from the model are described. The lecture concludes with a description of how models can be tested experimentally and modified when the details of the models and the resultant predictive behavior are not confirmed by experimentation.
*Contact information. E-mail, ravi.iyengar{at}mssm.edu
Citation: R. Iyengar, Quantitative Models of Mammalian Cell Signaling Pathways. Sci. Signal. 1, tr1 (2008).
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