Science Signaling Podcast: 15 December 2009

Paul S. Mischel ^{1 , 2 , 3} and Annalisa M. VanHook ⁴

¹ Department of Pathology and Laboratory Medicine, David Geffen UCLA School of Medicine, Los Angeles, CA 90095, USA.
² Henry Singleton Brain Tumor Program and Jonsson Comprehensive Cancer Center, David Geffen UCLA School of Medicine, Los Angeles, CA 90095, USA.
³ Molecular and Medical Pharmacology, David Geffen UCLA School of Medicine, Los Angeles, CA 90095, USA.
⁴ Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.

Abstract: This is a conversation with Paul Mischel about a Research Article published in the 15 December 2009 issue of Science Signaling.

The editors suggest the following Related Resources on Science sites:

In Science Signaling

RESEARCH ARTICLES
Cancer
EGFR Signaling Through an Akt-SREBP-1–Dependent, Rapamycin-Resistant Pathway Sensitizes Glioblastomas to Antilipogenic Therapy

Deliang Guo, Robert M. Prins, Julie Dang, Daisuke Kuga, Akio Iwanami, Horacio Soto, Kelly Y. Lin, Tiffany T. Huang, David Akhavan, M. Benjamin Hock, Shaojun Zhu, Ava A. Kofman, Steve J. Bensinger, William H. Yong, Harry V. Vinters, Steve Horvath, Andrew D. Watson, John G. Kuhn, H. Ian Robins, Minesh P. Mehta, Patrick Y. Wen, Lisa M. DeAngelis, Michael D. Prados, Ingo K. Mellinghoff, Timothy F. Cloughesy, and Paul S. Mischel (15 December 2009)
Sci. Signal. 2 (101), ra82. [DOI: 10.1126/scisignal.2000446]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

PERSPECTIVES
Cancer
PKM2 Tyrosine Phosphorylation and Glutamine Metabolism Signal a Different View of the Warburg Effect

Chi V. Dang (17 November 2009)
Sci. Signal. 2 (97), pe75. [DOI: 10.1126/scisignal.297pe75]
 |  Abstract »  |  Full Text »  |  PDF »

RESEARCH ARTICLES
Cancer
Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth

Taro Hitosugi, Sumin Kang, Matthew G. Vander Heiden, Tae-Wook Chung, Shannon Elf, Katherine Lythgoe, Shaozhong Dong, Sagar Lonial, Xu Wang, Georgia Z. Chen, Jianxin Xie, Ting-Lei Gu, Roberto D. Polakiewicz, Johannes L. Roesel, Titus J. Boggon, Fadlo R. Khuri, D. Gary Gilliland, Lewis C. Cantley, Jonathan Kaufman, and Jing Chen (17 November 2009)
Sci. Signal. 2 (97), ra73. [DOI: 10.1126/scisignal.2000431]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

EDITORS' CHOICE
EGF Signaling
More Than Just Constitutively Active

Annalisa M. VanHook (7 October 2008)
Sci. Signal. 1 (40), ec347. [DOI: 10.1126/scisignal.140ec347]
 |  Abstract »

EDITORS' CHOICE
Medicine
Cancer Genomes: From Chaos Comes Order?

Paula A. Kiberstis (30 September 2008)
Sci. Signal. 1 (39), ec340. [DOI: 10.1126/scisignal.139ec340]
 |  Abstract »

EDITORS' CHOICE
Cancer
A Deadly Gift

Elizabeth M. Adler (13 May 2008)
Sci. Signal. 1 (19), ec172. [DOI: 10.1126/stke.119ec172]
 |  Abstract »

EDITORS' CHOICE
Medicine
Slowing Tumor Growth with a One-Two Punch

Paula A. Kiberstis (16 October 2007)
Sci. STKE 2007 (408), tw377. [DOI: 10.1126/stke.4082007tw377]
 |  Abstract »

PERSPECTIVES
Cancer
Metabolic Targeting as an Anticancer Strategy: Dawn of a New Era?

James G. Pan and Tak W. Mak (10 April 2007)
Sci. STKE 2007 (381), pe14. [DOI: 10.1126/stke.3812007pe14]
 |  Abstract »  |  Full Text »  |  PDF »