Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 20 January 2009
Vol. 2, Issue 54, p. cm1
[DOI: 10.1126/scisignal.254cm1]

CONNECTIONS MAP OVERVIEWS

Neuro2A Differentiation by G{alpha}i/o Pathway

Avi Ma'ayan*, Sherry L. Jenkins, Alexander Barash, and Ravi Iyengar

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

Abstract: Signaling from Gi/o-coupled G protein–coupled receptors (GPCRs), such as the serotonin 1B, cannabinoid 1, and dopamine D2 receptors, inhibits cAMP production by adenylyl cyclases and activates protein kinases, such as Src, mitogen-activated protein kinases 1 and 2, and Akt. Activation of these protein kinases results in stimulation of neurite outgrowth in the central nervous system (CNS) and in neuronal cell lines. This Connections Map traces downstream signaling pathways from Gi/o-coupled GPCRs to key protein kinases and key transcription factors involved in neuronal differentiation. Components in the Science Signaling Connections Map are linked to Nature Molecule Pages. This interoperability provides ready access to detail that includes information about specific states for the nodes.

* Corresponding author. E-mail: avi.maayan{at}mssm.edu

Citation: A. Ma'ayan, S. L. Jenkins, A. Barash, R. Iyengar, Neuro2A Differentiation by G{alpha}i/o Pathway. Sci. Signal. 2, cm1 (2009).

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Genes Encoding Heterotrimeric G-proteins Are Associated with Gray Matter Volume Variations in the Medial Frontal Cortex.
I. Chavarria-Siles, M. Rijpkema, E. Lips, A. Arias-Vasquez, M. Verhage, B. Franke, G. Fernandez, and D. Posthuma (2013)
Cereb Cortex 23, 1025-1030
   Abstract »    Full Text »    PDF »
Optically triggering spatiotemporally confined GPCR activity in a cell and programming neurite initiation and extension.
W. K. A. Karunarathne, L. Giri, V. Kalyanaraman, and N. Gautam (2013)
PNAS 110, E1565-E1574
   Abstract »    Full Text »    PDF »
Inhibitory responses in Aplysia pleural sensory neurons act to block excitability, transmitter release, and PKC Apl II activation.
T. W. Dunn, C. A. Farah, and W. S. Sossin (2012)
J Neurophysiol 107, 292-305
   Abstract »    Full Text »    PDF »
AT1R-CB1R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II.
R. Rozenfeld, A. Gupta, K. Gagnidze, M. P. Lim, I. Gomes, D. Lee-Ramos, N. Nieto, and L. A. Devi (2011)
EMBO J. 30, 2350-2363
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882