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Sci. Signal., 20 January 2009
Vol. 2, Issue 54, p. pe4
[DOI: 10.1126/scisignal.254pe4]

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Protein Kinase Activation Loop Autophosphorylation in Cis: Overcoming a Catch-22 Situation

Pamela A. Lochhead*

The Laboratory of Molecular Signalling, The Babraham Research Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.

Abstract: Autophosphorylation of the activation loop in cis is an underappreciated and poorly understood mode of activation of protein kinases. Here, I describe four examples of protein kinases that are activated in this way, concentrating on their biochemical properties and how their autophosphorylation in cis is achieved.

* Corresponding author. E-mail: pamela.lochhead{at}bbsrc.ac.uk

Citation: P. A. Lochhead, Protein Kinase Activation Loop Autophosphorylation in Cis: Overcoming a Catch-22 Situation. Sci. Signal. 2, pe4 (2009).

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