Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Subscribe

Sci. Signal., 3 February 2009
Vol. 2, Issue 56, p. pe6
[DOI: 10.1126/scisignal.256pe6]

PERSPECTIVES

Extracellular ATP in the Immune System: More Than Just a "Danger Signal"

Alain Trautmann

Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), Paris, France. Inserm, U567, Paris, France.

Abstract: Extracellular adenosine 5'-triphosphate (eATP) is ubiquitously used for cell-to-cell communication. The low concentration of eATP ([eATP]) that exists in a "halo" surrounding resting cells signals the presence of neighboring living cells. Transient increases in [eATP] are used for basic physiological signaling, namely, in the nervous and vascular systems. Larger increases in [eATP] that are associated with cell death serve as a key "danger" signal in inflammatory processes. Two studies now point to roles for ATP in the immune system: providing a costimulatory signal to T cells and driving the differentiation of intestinal T helper 17 (TH17) cells.

* Corresponding author. E-mail: alain.trautmann{at}inserm.fr

Citation: A. Trautmann, Extracellular ATP in the Immune System: More Than Just a "Danger Signal". Sci. Signal. 2, pe6 (2009).

Read the Full Text

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Ecto-Nucleoside Triphosphate Diphosphohydrolase 7 Controls Th17 Cell Responses through Regulation of Luminal ATP in the Small Intestine.
T. Kusu, H. Kayama, M. Kinoshita, S. G. Jeon, Y. Ueda, Y. Goto, R. Okumura, H. Saiga, T. Kurakawa, K. Ikeda, et al. (2013)
J. Immunol. 190, 774-783
   Abstract »    Full Text »    PDF »
Reversible Inhibition of Chlamydia trachomatis Infection in Epithelial Cells Due to Stimulation of P2X4 Receptors.
M. A. Pettengill, C. Marques-da-Silva, M. L. Avila, S. d'Arc dos Santos Oliveira, V. W. Lam, I. Ollawa, A. A. Abdul Sater, R. Coutinho-Silva, G. Hacker, and D. M. Ojcius (2012)
Infect. Immun. 80, 4232-4238
   Abstract »    Full Text »    PDF »
P2X7 receptor activation induces inflammatory responses in salivary gland epithelium.
L. T. Woods, J. M. Camden, J. M. Batek, M. J. Petris, L. Erb, and G. A. Weisman (2012)
Am J Physiol Cell Physiol 303, C790-C801
   Abstract »    Full Text »    PDF »
Extracellular ATP Exerts Opposite Effects on Activated and Regulatory CD4+ T Cells via Purinergic P2 Receptor Activation.
S. Trabanelli, D. Ocadlikova, S. Gulinelli, A. Curti, V. Salvestrini, R. de Paula Vieira, M. Idzko, F. Di Virgilio, D. Ferrari, and R. M. Lemoli (2012)
J. Immunol. 189, 1303-1310
   Abstract »    Full Text »    PDF »
A2A Adenosine Receptor Signaling in Lymphocytes and the Central Nervous System Regulates Inflammation during Experimental Autoimmune Encephalomyelitis.
J. H. Mills, D.-G. Kim, A. Krenz, J.-F. Chen, and M. S. Bynoe (2012)
J. Immunol. 188, 5713-5722
   Abstract »    Full Text »    PDF »
Real-time Imaging Reveals That P2Y2 and P2Y12 Receptor Agonists Are Not Chemoattractants and Macrophage Chemotaxis to Complement C5a Is Phosphatidylinositol 3-Kinase (PI3K)- and p38 Mitogen-activated Protein Kinase (MAPK)-independent.
K. Isfort, F. Ebert, J. Bornhorst, S. Sargin, R. Kardakaris, M. Pasparakis, M. Bahler, T. Schwerdtle, A. Schwab, and P. J. Hanley (2011)
J. Biol. Chem. 286, 44776-44787
   Abstract »    Full Text »    PDF »
NF-{kappa}B Protects Cells from Gamma Interferon-Induced RIP1-Dependent Necroptosis.
R. J. Thapa, S. H. Basagoudanavar, S. Nogusa, K. Irrinki, K. Mallilankaraman, M. J. Slifker, A. A. Beg, M. Madesh, and S. Balachandran (2011)
Mol. Cell. Biol. 31, 2934-2946
   Abstract »    Full Text »    PDF »
Identification of an Arabidopsis Plasma Membrane-Located ATP Transporter Important for Anther Development.
B. Rieder and H. E. Neuhaus (2011)
PLANT CELL 23, 1932-1944
   Abstract »    Full Text »    PDF »
Dangers Within: DAMP Responses to Damage and Cell Death in Kidney Disease.
D. L. Rosin and M. D. Okusa (2011)
J. Am. Soc. Nephrol. 22, 416-425
   Abstract »    Full Text »    PDF »
Mycobacterium tuberculosis Synergizes with ATP To Induce Release of Microvesicles and Exosomes Containing Major Histocompatibility Complex Class II Molecules Capable of Antigen Presentation.
L. Ramachandra, Y. Qu, Y. Wang, C. J. Lewis, B. A. Cobb, K. Takatsu, W. H. Boom, G. R. Dubyak, and C. V. Harding (2010)
Infect. Immun. 78, 5116-5125
   Abstract »    Full Text »    PDF »
Dexamethasone Enhances ATP-Induced Inflammatory Responses in Endothelial Cells.
Y. Ding, Z.-G. Gao, K. A. Jacobson, and A. F. Suffredini (2010)
J. Pharmacol. Exp. Ther. 335, 693-702
   Abstract »    Full Text »    PDF »
The hidden life of NAD+-consuming ectoenzymes in the endocrine system.
F. Malavasi, S. Deaglio, G. Zaccarello, A. L. Horenstein, A. Chillemi, V. Audrito, S. Serra, M. Gandione, A. Zitella, and A. Tizzani (2010)
J. Mol. Endocrinol. 45, 183-191
   Abstract »    Full Text »    PDF »
Biglycan, a Danger Signal That Activates the NLRP3 Inflammasome via Toll-like and P2X Receptors.
A. Babelova, K. Moreth, W. Tsalastra-Greul, J. Zeng-Brouwers, O. Eickelberg, M. F. Young, P. Bruckner, J. Pfeilschifter, R. M. Schaefer, H.-J. Grone, et al. (2009)
J. Biol. Chem. 284, 24035-24048
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882