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Sci. Signal., 10 February 2009
Vol. 2, Issue 57, p. mr1
[DOI: 10.1126/scisignal.257mr1]


Emerging Roles of NAD+ and Its Metabolites in Cell Signaling

Friedrich Koch-Nolte1*, Friedrich Haag1, Andreas H. Guse2, Frances Lund3, and Mathias Ziegler4

1 Institute of Immunology, Diagnostic Department, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany.
2 The Calcium Signaling Group, Institute of Biochemistry and Molecular Biology I, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany.
3 Division of Allergy, Immunology, and Rheumatology, University of Rochester Medical Center, 601 Elmwood Drive, Rochester, NY 14642, USA.
4 Department of Molecular Biology, University of Bergen, Thormøhlensgate 55, N-5008 Bergen, Norway.

A report on the NAD2008 symposium, Hamburg, Germany, 14 to 17 September 2008.

Abstract: Nicotinamide adenine dinucleotide (NAD+) is the universal currency of energy metabolism and electron transfer. Recent studies indicate that apart from its role as a coenzyme, NAD+ and its metabolites also function in cell signaling pathways; for example, they are substrates for nucleotide-metabolizing enzymes and ligands for extra- and intracellular receptors and ion channels. Moreover, the NAD+ and NAD+ phosphate metabolites adenosine 5'-diphosphoribose (ADP-ribose), cyclic ADP-ribose, and nicotinic acid adenine dinucleotide phosphate (NAADP) have emerged as key second messengers in Ca2+ signaling. A symposium in Hamburg, Germany, brought together 120 researchers from various fields, who were all engaged in the molecular characterization of the key players of NAD+ signaling (

* Corresponding author. E-mail, nolte{at}

Citation: F. Koch-Nolte, F. Haag, A. H. Guse, F. Lund, M. Ziegler, Emerging Roles of NAD+ and Its Metabolites in Cell Signaling. Sci. Signal. 2, mr1 (2009).

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