Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Sci. Signal., 10 February 2009
Vol. 2, Issue 57, p. mr1
[DOI: 10.1126/scisignal.257mr1]
MEETING REPORTS
Emerging Roles of NAD+ and Its Metabolites in Cell Signaling
Friedrich Koch-Nolte1*,
Friedrich Haag1,
Andreas H. Guse2,
Frances Lund3, and
Mathias Ziegler4
1 Institute of Immunology, Diagnostic Department, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany. 2 The Calcium Signaling Group, Institute of Biochemistry and Molecular Biology I, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany. 3 Division of Allergy, Immunology, and Rheumatology, University of Rochester Medical Center, 601 Elmwood Drive, Rochester, NY 14642, USA. 4 Department of Molecular Biology, University of Bergen, Thormøhlensgate 55, N-5008 Bergen, Norway.
A report on the NAD2008 symposium, Hamburg, Germany, 14 to 17 September 2008.
Abstract:
Nicotinamide adenine dinucleotide (NAD+) is the universal currency of energy metabolism and electron transfer. Recent studies indicate that apart from its role as a coenzyme, NAD+ and its metabolites also function in cell signaling pathways; for example, they are substrates for nucleotide-metabolizing enzymes and ligands for extra- and intracellular receptors and ion channels. Moreover, the NAD+ and NAD+ phosphate metabolites adenosine 5'-diphosphoribose (ADP-ribose), cyclic ADP-ribose, and nicotinic acid adenine dinucleotide phosphate (NAADP) have emerged as key second messengers in Ca2+ signaling. A symposium in Hamburg, Germany, brought together 120 researchers from various fields, who were all engaged in the molecular characterization of the key players of NAD+ signaling (www.NAD2008.de).
* Corresponding author. E-mail, nolte{at}uke.de
Citation: F. Koch-Nolte, F. Haag, A. H. Guse, F. Lund, M. Ziegler, Emerging Roles of NAD+ and Its Metabolites in Cell Signaling. Sci. Signal.2, mr1 (2009).
Andreas H. Guse (24 April 2012) Sci. Signal.5 (221), pe18.
[DOI: 10.1126/scisignal.2002890] |Abstract »|Full Text »|PDF »
MEETING REPORTS
Michael O. Hottiger, Mark Boothby, Friedrich Koch-Nolte, Bernhard Lüscher, Niall M. B. Martin, Ruth Plummer, Zhao-Qi Wang, and Mathias Ziegler (24 May 2011) Sci. Signal.4 (174), mr5.
[DOI: 10.1126/scisignal.2001645] |Abstract »|Full Text »|PDF »
EDITORS' CHOICE
Wei Wong (24 November 2009) Sci. Signal.2 (98), ec378.
[DOI: 10.1126/scisignal.298ec378] |Abstract »
REVIEWS
Andreas H. Guse and Hon Cheung Lee (4 November 2008) Sci. Signal.1 (44), re10.
[DOI: 10.1126/scisignal.144re10] |Gloss »|Abstract »|Full Text »|PDF »
PERSPECTIVES
Andreas H. Guse (29 April 2008) Sci. Signal.1 (17), pe18.
[DOI: 10.1126/stke.117pe18] |Abstract »|Full Text »|PDF »
EDITORS' CHOICE
Beverly A. Purnell (12 February 2008) Sci. Signal.1 (6), ec59.
[DOI: 10.1126/stke.16ec59] |Abstract »
PERSPECTIVES
Daniela Corda and Maria Di Girolamo (17 December 2002) Sci. STKE2002 (163), pe53.
[DOI: 10.1126/scisignal.1632002pe53] |Abstract »|Full Text »|PDF »
PERSPECTIVES
Hon Cheung Lee (11 July 2000) Sci. STKE2000 (40), pe1.
[DOI: 10.1126/scisignal.402000pe1] |Abstract »|Full Text »|PDF »
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Pyridine Nucleotide Regulation of Cardiac Intermediary Metabolism.
J. R. Ussher, J. S. Jaswal, and G. D. Lopaschuk (2012)
Circ. Res.
111, 628-641
|Abstract »|Full Text »|PDF »
ASPARTATE OXIDASE Plays an Important Role in Arabidopsis Stomatal Immunity.
A. P. Macho, F. Boutrot, J. P. Rathjen, and C. Zipfel (2012)
Plant Physiology
159, 1845-1856
|Abstract »|Full Text »|PDF »
Pharmacological Effects of Exogenous NAD on Mitochondrial Bioenergetics, DNA Repair, and Apoptosis.
M. Pittelli, R. Felici, V. Pitozzi, L. Giovannelli, E. Bigagli, F. Cialdai, G. Romano, F. Moroni, and A. Chiarugi (2011)
Mol. Pharmacol.
80, 1136-1146
|Abstract »|Full Text »|PDF »
Reciprocal Potentiation of the Antitumoral Activities of FK866, an Inhibitor of Nicotinamide Phosphoribosyltransferase, and Etoposide or Cisplatin in Neuroblastoma Cells.
C. Travelli, V. Drago, E. Maldi, N. Kaludercic, U. Galli, R. Boldorini, F. Di Lisa, G. C. Tron, P. L. Canonico, and A. A. Genazzani (2011)
J. Pharmacol. Exp. Ther.
338, 829-840
|Abstract »|Full Text »|PDF »
Nicotinamide adenine dinucleotide (NAD)-regulated DNA methylation alters CCCTC-binding factor (CTCF)/cohesin binding and transcription at the BDNF locus.
J. Chang, B. Zhang, H. Heath, N. Galjart, X. Wang, and J. Milbrandt (2010)
PNAS
107, 21836-21841
|Abstract »|Full Text »|PDF »
Inhibition of Nicotinamide Phosphoribosyltransferase: CELLULAR BIOENERGETICS REVEALS A MITOCHONDRIAL INSENSITIVE NAD POOL.
M. Pittelli, L. Formentini, G. Faraco, A. Lapucci, E. Rapizzi, F. Cialdai, G. Romano, G. Moneti, F. Moroni, and A. Chiarugi (2010)
J. Biol. Chem.
285, 34106-34114
|Abstract »|Full Text »|PDF »
Identification of Direct and Indirect Effectors of the Transient Receptor Potential Melastatin 2 (TRPM2) Cation Channel.
Diadenosine Homodinucleotide Products of ADP-ribosyl Cyclases Behave as Modulators of the Purinergic Receptor P2X7.
S. Bruzzone, G. Basile, M. P. Chothi, L. Nobbio, C. Usai, E. Jacchetti, A. Schenone, A. H. Guse, F. Di Virgilio, A. De Flora, et al. (2010)
J. Biol. Chem.
285, 21165-21174
|Abstract »|Full Text »|PDF »
