Science Signaling Podcast: 03 March 2009

Joseph Schlessinger¹ and Annalisa M. VanHook²

¹ Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520.
² Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.

Abstract: This is a conversation with Joseph Schlessinger, senior author of a Research Article published in the 17 February issue of Science Signaling. He discusses his group's recent characterization of the kinetics of fibroblast growth factor receptor autophosphorylation.

The editors suggest the following Related Resources on Science sites:

In Science Signaling

RESEARCH ARTICLES
Cancer
EGFR Signaling Through an Akt-SREBP-1–Dependent, Rapamycin-Resistant Pathway Sensitizes Glioblastomas to Antilipogenic Therapy

Deliang Guo, Robert M. Prins, Julie Dang, Daisuke Kuga, Akio Iwanami, Horacio Soto, Kelly Y. Lin, Tiffany T. Huang, David Akhavan, M. Benjamin Hock, Shaojun Zhu, Ava A. Kofman, Steve J. Bensinger, William H. Yong, Harry V. Vinters, Steve Horvath, Andrew D. Watson, John G. Kuhn, H. Ian Robins, Minesh P. Mehta, Patrick Y. Wen, Lisa M. DeAngelis, Michael D. Prados, Ingo K. Mellinghoff, Timothy F. Cloughesy, and Paul S. Mischel (15 December 2009)
Sci. Signal. 2 (101), ra82. [DOI: 10.1126/scisignal.2000446]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

EDITORS' CHOICE
Receptors
Promoting Dimerization

Elizabeth M. Adler (19 May 2009)
Sci. Signal. 2 (71), ec168. [DOI: 10.1126/scisignal.271ec168]
 |  Abstract »

RESEARCH ARTICLES
Biochemistry
The Precise Sequence of FGF Receptor Autophosphorylation Is Kinetically Driven and Is Disrupted by Oncogenic Mutations

Erin D. Lew, Cristina M. Furdui, Karen S. Anderson, and Joseph Schlessinger (17 February 2009)
Sci. Signal. 2 (58), ra6. [DOI: 10.1126/scisignal.2000021]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

PERSPECTIVES
Biochemistry
Protein Kinase Activation Loop Autophosphorylation in Cis: Overcoming a Catch-22 Situation

Pamela A. Lochhead (20 January 2009)
Sci. Signal. 2 (54), pe4. [DOI: 10.1126/scisignal.254pe4]
 |  Abstract »  |  Full Text »  |  PDF »

REVIEWS
STKE Reviews
SH2 and PTB Domains in Tyrosine Kinase Signaling

Joseph Schlessinger and Mark A. Lemmon (15 July 2003)
Sci. STKE 2003 (191), re12. [DOI: 10.1126/scisignal.1912003re12]
 |  Gloss »  |  Abstract »  |  Full Text »  |  PDF »