Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 24 March 2009
Vol. 2, Issue 63, p. pe15
[DOI: 10.1126/scisignal.263pe15]

PERSPECTIVES

Challenges and Opportunities in Defining the Essential Cancer Kinome

Brendan D. Manning*

Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.

Abstract: Signaling pathways controlled by protein kinases underlie a large fraction of human diseases and participate in the development and progression of all forms of cancer. Targeted therapeutic strategies to treat cancer and other diseases are focused almost exclusively on protein kinases, with a strong bias toward a small subset of the entire human kinome. RNA interference (RNAi)–based screens for protein kinase requirements have revealed a surprisingly high degree of diversity between cancer cell lines in their dependence on specific protein kinases. These screens also demonstrate that some of the most critical protein kinases for the proliferation and survival of cancer cell lines are also the least studied. Although the concept of oncogene addiction is powerful in designing therapeutic strategies to treat cancer, unbiased kinome-specific and genome-wide RNAi screens are revealing unexploited areas of potential therapeutic intervention.

* Contact information. E-mail, bmanning{at}hsph.harvard.edu

Citation: B. D. Manning, Challenges and Opportunities in Defining the Essential Cancer Kinome. Sci. Signal. 2, pe15 (2009).

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Outlier Kinase Expression by RNA Sequencing as Targets for Precision Therapy.
V. Kothari, I. Wei, S. Shankar, S. Kalyana-Sundaram, L. Wang, L. W. Ma, P. Vats, C. S. Grasso, D. R. Robinson, Y.-M. Wu, et al. (2013)
Cancer Discovery 3, 280-293
   Abstract »    Full Text »    PDF »
Phosphoproteomic Analysis of Leukemia Cells under Basal and Drug-treated Conditions Identifies Markers of Kinase Pathway Activation and Mechanisms of Resistance.
M. P. Alcolea, P. Casado, J.-C. Rodriguez-Prados, B. Vanhaesebroeck, and P. R. Cutillas (2012)
Mol. Cell. Proteomics 11, 453-466
   Abstract »    Full Text »    PDF »
The Role of p27Kip1 in Dasatinib-Enhanced Paclitaxel Cytotoxicity in Human Ovarian Cancer Cells.
X.-F. Le, W. Mao, G. He, F.-X. Claret, W. Xia, A. A. Ahmed, M.-C. Hung, Z. H. Siddik, and R. C. Bast Jr (2011)
J Natl Cancer Inst 103, 1403-1422
   Abstract »    Full Text »    PDF »
Tales from an academic RNAi screening facility; FAQs.
M. Jiang, R. Instrell, B. Saunders, H. Berven, and M. Howell (2011)
Briefings in Functional Genomics 10, 227-237
   Abstract »    Full Text »    PDF »
Science Signaling Podcast: 07 April 2009.
B. D. Manning and A. M. VanHook (2009)
Science Signaling 2, pc7
   Abstract »    Full Text »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882