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Sci. Signal., 21 April 2009
Vol. 2, Issue 67, p. pe24
[DOI: 10.1126/scisignal.267pe24]

PERSPECTIVES

The Pharmacology of mTOR Inhibition

David A. Guertin1 and David M. Sabatini1,2,3*

1 Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02141, USA.
2 Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
3 Koch Center for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

Abstract: A flurry of reports indicates that we are entering a new phase in the development of mammalian target of rapamycin (mTOR)–based therapies for oncology. Here, we summarize exciting findings regarding mTOR signaling and the outlook for mTOR inhibitors as tools to study the mTOR pathway and as drugs in the clinic.

* Corresponding author. Telephone, 617-258-6407; e-mail, sabatini{at}wi.mit.edu

Citation: D. A. Guertin, D. M. Sabatini, The Pharmacology of mTOR Inhibition. Sci. Signal. 2, pe24 (2009).

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