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Sci. Signal., 21 April 2009
Vol. 2, Issue 67, p. pe27
[DOI: 10.1126/scisignal.267pe27]

PERSPECTIVES

New Insights into mTOR Signaling: mTORC2 and Beyond

Dario R. Alessi*, Laura R. Pearce, and Juan M. García-Martínez

MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK.

Abstract: The mammalian target of rapamycin complex 2 (mTORC2) plays critical roles in regulating cell growth and proliferation. mTORC2 promotes the activation of the serum glucocorticoid–induced protein kinase (SGK). This mTOR complex also promotes the constitutive phosphorylation of proline-directed serine or threonine sites in the turn motif of Akt and protein kinase C isoforms. mTORC2 may control phosphorylation of the turn motif by promoting the activity of a kinase that targets the Ser/Thr-Pro sequence or by inhibiting the activity of a phosphatase.

* Corresponding author. E-mail, d.r.alessi{at}dundee.ac.uk

Citation: D. R. Alessi, L. R. Pearce, J. M. García-Martínez, New Insights into mTOR Signaling: mTORC2 and Beyond. Sci. Signal. 2, pe27 (2009).

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