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Sci. Signal., 28 April 2009
Vol. 2, Issue 68, p. pe28
[DOI: 10.1126/scisignal.268pe28]


Nontraditional Signaling Mechanisms of Lipoprotein Receptors

G. William Rebeck*

Department of Neuroscience, Georgetown University, Washington, DC 20007, USA.

Abstract: The low-density lipoprotein receptor family consists of a large number of single transmembrane proteins that are involved both in endocytosis of extracellular ligands and in intracellular signaling processes. New evidence ties these receptors to the transactivation of Trk receptors. Thus, this single receptor family demonstrates several distinct mechanisms for transducing information across the plasma membrane.

* Corresponding author. E-mail, gwr2{at}

Citation: G. W. Rebeck, Nontraditional Signaling Mechanisms of Lipoprotein Receptors. Sci. Signal. 2, pe28 (2009).

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