Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. Signal., 28 April 2009
Vol. 2, Issue 68, p. pe28
[DOI: 10.1126/scisignal.268pe28]

PERSPECTIVES

Nontraditional Signaling Mechanisms of Lipoprotein Receptors

G. William Rebeck*

Department of Neuroscience, Georgetown University, Washington, DC 20007, USA.

Abstract: The low-density lipoprotein receptor family consists of a large number of single transmembrane proteins that are involved both in endocytosis of extracellular ligands and in intracellular signaling processes. New evidence ties these receptors to the transactivation of Trk receptors. Thus, this single receptor family demonstrates several distinct mechanisms for transducing information across the plasma membrane.

* Corresponding author. E-mail, gwr2{at}georgetown.edu

Citation: G. W. Rebeck, Nontraditional Signaling Mechanisms of Lipoprotein Receptors. Sci. Signal. 2, pe28 (2009).

Read the Full Text

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
LDL receptor-related protein-1 is a sialic-acid-independent receptor for myelin-associated glycoprotein that functions in neurite outgrowth inhibition by MAG and CNS myelin.
T. L. Stiles, T. L. Dickendesher, A. Gaultier, A. Fernandez-Castaneda, E. Mantuano, R. J. Giger, and S. L. Gonias (2013)
J. Cell Sci. 126, 209-220
   Abstract »    Full Text »    PDF »
Low Density Lipoprotein Receptor-related Protein (LRP1) Regulates Rac1 and RhoA Reciprocally to Control Schwann Cell Adhesion and Migration.
E. Mantuano, M. Jo, S. L. Gonias, and W. M. Campana (2010)
J. Biol. Chem. 285, 14259-14266
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882