Signaling by Gasotransmitters

Asif K. Mustafa¹, Moataz M. Gadalla², and Solomon H. Snyder^1,2,3*

¹ Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
² Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
³ Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract: Nitric oxide is well established as a major signaling molecule. Evidence is accumulating that carbon monoxide and hydrogen sulfide also are physiologic mediators in the cardiovascular, immune, and nervous systems. This Review focuses on mechanisms whereby they signal by binding to metal centers in metalloproteins, such as in guanylyl cyclase, or modifying sulfhydryl groups in protein targets.

* Corresponding author. E-mail: ssnyder{at}jhmi.edu

The editors suggest the following Related Resources on Science sites:

In Science Signaling

PODCASTS
Posttranslational Modifications
Science Signaling Podcast: 10 November 2009

Solomon H. Snyder and Annalisa M. VanHook (10 November 2009)
Sci. Signal. 2 (96), pc20. [DOI: 10.1126/scisignal.296pc20]
 |  Abstract »  |  Full Text »  |  Podcast »

RESEARCH
Posttranslational Modifications
H₂S Signals Through Protein S-Sulfhydration

Asif K. Mustafa, Moataz M. Gadalla, Nilkantha Sen, Seyun Kim, Weitong Mu, Sadia K. Gazi, Roxanne K. Barrow, Guangdong Yang, Rui Wang, and Solomon H. Snyder (10 November 2009)
Sci. Signal. 2 (96), ra72. [DOI: 10.1126/scisignal.2000464]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

EDITORIAL GUIDES
Cell Biology
Focus Issue: The Long and Short of Redox Signaling

Nancy R. Gough (29 September 2009)
Sci. Signal. 2 (90), eg12. [DOI: 10.1126/scisignal.290eg12]
 |  Abstract »  |  Full Text »  |  PDF »

EDITORS' CHOICE
Microbiology
It’s a Gas

Caroline Ash (15 September 2009)
Sci. Signal. 2 (88), ec303. [DOI: 10.1126/scisignal.288ec303]
 |  Abstract »

EDITORS' CHOICE
Hypertension
The Skinny on Blood Pressure?

Elizabeth M. Adler (12 May 2009)
Sci. Signal. 2 (70), ec160. [DOI: 10.1126/scisignal.270ec160]
 |  Abstract »

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES: