Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 5 May 2009
Vol. 2, Issue 69, p. pe29
[DOI: 10.1126/scisignal.269pe29]

PERSPECTIVES

Nitric Oxide Links Mitochondrial Fission to Alzheimer’s Disease

Benedikt Westermann*

Institut für Zellbiologie and Bayreuther Zentrum für Molekulare Biowissenschaften, Universität Bayreuth, 95440 Bayreuth, Germany.

Abstract: Mitochondrial dysfunction is a hallmark of β-amyloid (Aβ)–induced neuronal injury in the pathogenesis of Alzheimer’s disease. Neurotoxic Aβ peptide, thought to be a key mediator of Alzheimer’s disease, may be imported into human brain mitochondria, where it inhibits key enzymes of respiratory metabolism. Nitric oxide (NO) produced in response to Aβ induces S-nitrosylation of the mitochondrial division protein, dynamin-related protein 1 (Drp-1), which leads to excessive mitochondrial fission, synaptic loss, and neuronal damage. Furthermore, brains of patients with Alzheimer’s disease contain high amounts of S-nitrosylated Drp-1. Aβ-dependent mitochondrial fragmentation likely enhances the decline in bioenergetic capacity of damaged mitochondria and therefore contributes to neuronal injury and pathogenesis of Alzheimer’s disease.

* Corresponding author. E-mail, benedikt.westermann{at}uni-bayreuth.de

Citation: B. Westermann, Nitric Oxide Links Mitochondrial Fission to Alzheimer’s Disease. Sci. Signal. 2, pe29 (2009).

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
SNO-ing at the Nociceptive Synapse?.
I. Tegeder, R. Scheving, I. Wittig, and G. Geisslinger (2011)
Pharmacol. Rev. 63, 366-389
   Abstract »    Full Text »    PDF »
Inducible Nitric Oxide Synthase-Mediated Alteration of Mitochondrial OPA1 Expression in Ocular Hypertensive Rats.
Y. Dai, R. N. Weinreb, K.-Y. Kim, D. Nguyen, S. Park, X. Sun, J. D. Lindsey, M. H. Ellisman, and W.-K. Ju (2011)
Invest. Ophthalmol. Vis. Sci. 52, 2468-2476
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882