Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 22 September 2009
Vol. 2, Issue 89, p. pe58
[DOI: 10.1126/scisignal.289pe58]

PERSPECTIVES

Integrin Proteomes Reveal a New Guide for Cell Motility

Erik H. J. Danen*

Division of Toxicology, Leiden Amsterdam Center for Drug Research, Leiden University, Leiden, Netherlands.

Abstract: Integrin transmembrane receptors orchestrate signaling cascades by recruiting cytoskeletal linker proteins and enzymes to sites of cell adhesion. A proteomics-based view of such integrin-associated signaling networks is now available. Besides the usual suspects, the interactomes contain several proteins that were not previously connected to integrins. One of these, regulator of chromosome condensation–2 (RCC2), represents an unexpected molecular connection between integrins and the cell-migration machinery.

* Corresponding author. E-mail, e.danen{at}lacdr.leidenuniv.nl

Citation: E. H. J. Danen, Integrin Proteomes Reveal a New Guide for Cell Motility. Sci. Signal. 2, pe58 (2009).

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Tetraspan TM4SF5-dependent direct activation of FAK and metastatic potential of hepatocarcinoma cells.
O. Jung, S. Choi, S.-B. Jang, S.-A. Lee, S.-T. Lim, Y.-J. Choi, H.-J. Kim, D.-H. Kim, T. K. Kwak, H. Kim, et al. (2012)
J. Cell Sci. 125, 5960-5973
   Abstract »    Full Text »    PDF »
Cell Adhesion-dependent Serine 85 Phosphorylation of Paxillin Modulates Focal Adhesion Formation and Haptotactic Migration via Association with the C-terminal Tail Domain of Talin.
T. K. Kwak, M.-S. Lee, J. Ryu, Y.-J. Choi, M. Kang, D. Jeong, and J. W. Lee (2012)
J. Biol. Chem. 287, 27499-27509
   Abstract »    Full Text »    PDF »
Comparative Proteomic Analysis of a Cytosolic Fraction from {beta}3 Integrin-deficient Cells.
J. A. Bush, H. Kitaura, Y. Ma, S. L. Teitelbaum, F. P. Ross, and J. W. Smith (2012)
Cancer Genomics Proteomics 9, 1-13
   Abstract »    Full Text »    PDF »
Structures and Interaction Analyses of Integrin {alpha}M{beta}2 Cytoplasmic Tails.
G.-L. Chua, X.-Y. Tang, M. Amalraj, S.-M. Tan, and S. Bhattacharjya (2011)
J. Biol. Chem. 286, 43842-43854
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882