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Sci. Signal., 22 September 2009
Vol. 2, Issue 89, p. pe58
Integrin Proteomes Reveal a New Guide for Cell Motility
Erik H. J. Danen*
Division of Toxicology, Leiden Amsterdam Center for Drug Research, Leiden University, Leiden, Netherlands.
Integrin transmembrane receptors orchestrate signaling cascades by recruiting cytoskeletal linker proteins and enzymes to sites of cell adhesion. A proteomics-based view of such integrin-associated signaling networks is now available. Besides the usual suspects, the interactomes contain several proteins that were not previously connected to integrins. One of these, regulator of chromosome condensation–2 (RCC2), represents an unexpected molecular connection between integrins and the cell-migration machinery.
Hailing Cheng, Pixu Liu, Zhigang C. Wang, Lihua Zou, Stephanie Santiago, Victoria Garbitt, Ole V. Gjoerup, J. Dirk Iglehart, Alexander Miron, Andrea L. Richardson, William C. Hahn, and Jean J. Zhao (21 July 2009) Sci. Signal.2 (80), ra35.
[DOI: 10.1126/scisignal.2000369] |Editor's Summary »|Abstract »|Full Text »|PDF »|Supplementary Materials »