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Sci. STKE, 29 August 2000
Vol. 2000, Issue 47, p. pe1
[DOI: 10.1126/scisignal.472000pe1]

PERSPECTIVES

Tales from the Crypt: Evidence for Heptahelical Receptor Signaling in the Endocytic Pathway

Jennifer Whistler, Eric Beattie, and Mark von Zastrow

J. Whistler is in the Department of Neurology, University of California, San Francisco, CA 94143-0984, USA.
E. Beattie is in the Department of Psychiatry, University of California, San Francisco, CA 94143-0984, USA.
M. von Zastrow is in the Departments of Psychiatry and Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143-0984, USA. E-mail: zastrow{at}itsa.ucsf.edu

Abstract: In certain circumstances, internalized receptors are able to continue signaling after endocytosis. Whistler et al. discuss how the interaction of heterotrimeric GTP-binding protein (G protein)-coupled receptors with arrestins and their subsequent endocytosis may contribute to activation of the mitogen-activated protein kinase pathway. This Perspective delves into the role that scaffolds may play in organizing and specifying downstream signaling events that occur after internalization of G protein-coupled receptors.

Citation: J. Whistler, E. Beattie, M. von Zastrow, Tales from the Crypt: Evidence for Heptahelical Receptor Signaling in the Endocytic Pathway. Sci. STKE 2000, pe1 (2000).

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