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Sci. STKE, 30 October 2001
Vol. 2001, Issue 106, p. pe37
[DOI: 10.1126/stke.2001.106.pe37]

PERSPECTIVES

Signaling By Fibroblast Growth Factors: The Inside Story

Mitchell Goldfarb

Department of Biochemistry and Molecular Biology, Box 1020, Mount Sinai School of Medicine, 1 Gustave Levy Place, New York, NY 10029, USA.

Summary: Polypeptide growth factors bind to the extracellular domains of cell surface receptors, triggering activation of receptor-intrinsic or receptor-associated protein kinases. Although this central thesis is widely accepted, one family of proteins, the fibroblast growth factors (FGFs), have for more than a decade attracted a research "counterculture" looking for direct FGF actions inside cells. Goldfarb discusses how the search for alternative signaling pathways is moving mainstream with the help of two recent publications reporting specific intracellular targets for FGF and FGF-like proteins.

Contact information: Telephone: 212-241-3394, fax: 212-860-9279, e-mail: Mitchell.Goldfarb{at}mssm.edu

Citation: M. Goldfarb, Signaling By Fibroblast Growth Factors: The Inside Story. Sci. STKE 2001, pe37 (2001).

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Promotion and Attenuation of FGF Signaling Through the Ras-MAPK Pathway.
M. Tsang and I. B. Dawid (2004)
Sci. STKE 2004, pe17
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