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Sci. STKE, 15 January 2002
Vol. 2002, Issue 115, p. pe3
[DOI: 10.1126/stke.2002.115.pe3]

PERSPECTIVES

Meeting at Mitosis: Cell Cycle-Specific Regulation of c-Src by RPTP{alpha}

Tomas Mustelin1* and Tony Hunter2

1Program of Signal Transduction, Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. E-mail:tmustelin{at}burnham-inst.org.
2Molecular and Cell Biology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. E-mail:hunter{at}salk.edu.

Summary: Exquisite regulation is required for cells to properly enter and exit the phases of the cell cycle. The transmembrane receptor-like protein tyrosine phosphatase RPTP{alpha}, an important protein that participates in the transition of the cell cycle from G2 to mitosis activates the protein tyrosine kinase c-Src in vivo. Mustelin and Hunter discuss new findings that describe the highly regulated activation of RPTP{alpha} and c-Src that occurs just before entry into the mitotic phase. These findings also raise several questions that pertain to redistribution of RPTP{alpha} in the cell, and the role of phosphorylation and dimerization in regulating RPTP{alpha} activity.

*Corresponding author. E-mail: tmustelin{at}burnham-inst.org

Citation: T. Mustelin, T. Hunter, Meeting at Mitosis: Cell Cycle-Specific Regulation of c-Src by RPTP{alpha}. Sci. STKE 2002, pe3 (2002).

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