Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 29 October 2002
Vol. 2002, Issue 156, p. tw398
[DOI: 10.1126/stke.2002.156.tw398]

EDITORS' CHOICE

GLUTAMATE RECEPTORS A Gentler Treatment for Stroke

Although N-methyl-D-aspartate (NMDA) receptors play an important role in stroke, simply blocking them would lead to many unwanted side effects. Aarts et al. suggest a novel approach to treat ischemic brain injury without blocking NMDA receptors. They constructed peptides that bind to molecular domains governing the interaction of NMDA receptors with the postsynaptic density protein PSD-95. Normal synaptic activity and the subsequent postsynaptic calcium influx remain intact but deleterious downstream neurotoxic signaling events are inhibited.

M. Aarts, Y. Liu, L. Liu, S. Besshoh, M. Arundine, J. W. Gurd, Y.-T. Wang, M. W. Salter, M. Tymianski, Treatment of ischemic brain damage by perturbing NMDA receptor-PSD-95 protein interactions. Science 298, 846-850 (2002). [Abstract] [Full Text]

Citation: A Gentler Treatment for Stroke. Sci. STKE 2002, tw398 (2002).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882