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Sci. STKE, 12 November 2002
Vol. 2002, Issue 158, p. tw417
[DOI: 10.1126/stke.2002.158.tw417]

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TRANSCRIPTION Picking a Signaling Pathway

How is specificity gained when numerous genes are regulated by a single transcription factor in response to diverse stimuli? Hoffman et al. (see the Perspective by Ting and Endy) examined how a transcription factor called nuclear factor-{kappa}B (NF-{kappa}B) is differentially controlled by three different isoforms of an inhibitor protein called I{kappa}B. They combined computational modeling with biochemical data that they obtained from genetically engineered cells that express only one I{kappa}B isoform. During the cell's exposure to a stimulus, a bimodal and temporal signal processing mechanism determines which I{kappa}B-NF-{kappa}B pathway and downstream target genes get activated.

A. Hoffmann, A. Levchenko, M. L. Scott, D. Baltimore, The I{kappa}B-NF-{kappa}B signaling module: Temporal control and selective gene activation. Science 298, 1241-1245 (2002). [Abstract] [Full Text]

A. Y. Ting, D. Endy, Decoding NF-{kappa}B signaling. Science 298, 1189-1190 (2002). [Summary] [Full Text]

Citation: Picking a Signaling Pathway. Sci. STKE 2002, tw417 (2002).

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