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Sci. STKE, 1 July 2003
Vol. 2003, Issue 189, p. pe24
[DOI: 10.1126/stke.2003.189.pe24]

PERSPECTIVES

Old Dogs and New Tricks, Proteases, Inhibitors, and Cell Migration

Steingrimur Stefansson and Daniel A. Lawrence*

Vascular Biology Department, Jerome H. Holland Laboratory for the Biomedical Sciences, American Red Cross, 15601 Crabbs Branch Way, Rockville, MD 20855, USA.

Summary: A new model for the actions of plasminogen activator inhibitors (PAIs) on cell migration may resolve the conflicting research data on these proteins in metastasis and angiogenesis. Results from two groups reveal a role for PAI-1 in promoting cycles of attachment and detachment of the cell from the extracellular matrix that is independent of its role as an enzymatic inhibitor of urokinase-type plasminogen activator (uPA). Through the formation of a complex of integrins, uPA and its receptor, and the clearance receptors of the low-density lipoprotein family, PAI-1 may promote endocytosis and recycling of these adhesion-controlling proteins, allowing cycling of cellular attachment and detachment.

*Corresponding author. Telephone, (301) 517-0356; fax, (301) 738-0497; e-mail, lawrenced{at}usa.redcross.org

Citation: S. Stefansson, D. A. Lawrence, Old Dogs and New Tricks, Proteases, Inhibitors, and Cell Migration. Sci. STKE 2003, pe24 (2003).

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