Membrane Recognition and Targeting by Lipid-Binding Domains

doi:10.1126/stke.2132003re16

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Sci. STKE, 16 December 2003
Vol. 2003, Issue 213, p. re16
[DOI: 10.1126/stke.2132003re16]

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Membrane Recognition and Targeting by Lipid-Binding Domains

Jonathan P. DiNitto, Thomas C. Cronin, and David G. Lambright^*

Program in Molecular Medicine and Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

Abstract: Modular domains that recognize and target intracellular membranes play a critical role in the assembly, localization, and function of signaling and trafficking complexes in eukaryotic cells. Large domain families, including PH, FYVE, PX, PHD, and C2 domains, combine specific, nonspecific, and multivalent interactions to achieve selective membrane targeting. Despite structural and functional diversity, general features of lipid recognition are evident in the various membrane-targeting mechanisms.

*Corresponding author. Telephone, 508-856-6876; fax, 508-856-4289; e-mail, David.Lambright{at}umassmed.edu

Citation: J. P. DiNitto, T. C. Cronin, D. G. Lambright, Membrane Recognition and Targeting by Lipid-Binding Domains. Sci. STKE 2003, re16 (2003).

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