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Sci. STKE, 3 February 2004
Vol. 2004, Issue 218, p. re3
[DOI: 10.1126/stke.2182004re3]

REVIEWS

G Protein Signaling: Insights from New Structures

Anita M. Preininger and Heidi E. Hamm*

Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232–6600, USA.

Abstract: A large body of experimental evidence exists that links heterotrimeric guanosine triphosphate–binding protein (G protein) structure to function. The determination of the crystal structures of G proteins in various activational states and, more recently, in complexes with effectors and other signaling partners highlights the varied mechanisms involved in G protein regulation. Signaling complexes, such as the recently solved complex of Gß{gamma} and G protein receptor kinase 2 (GRK2), provide new insights into the mechanisms underlying the regulation of these highly conserved signaling molecules. In this Review, we discuss the latest findings and their implications for G protein–signaling paradigms.

*Corresponding author. E-mail: heidi.hamm{at}vanderbilt.edu

Citation: A. M. Preininger, H. E. Hamm, G Protein Signaling: Insights from New Structures. Sci. STKE 2004, re3 (2004).

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