Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Sci. STKE, 2 March 2004
Vol. 2004, Issue 222, p. pe8
[DOI: 10.1126/stke.2222004pe8]

PERSPECTIVES

Molecular Interaction Maps--A Diagrammatic Graphical Language for Bioregulatory Networks

Mirit I. Aladjem1*, Stefania Pasa2, Silvio Parodi2, John N. Weinstein1, Yves Pommier1, and Kurt W. Kohn1*

1Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
2Laboratory of Experimental Oncology, National Institute of Cancer Research and University of Genoa, Genoa, Italy.

Summary: Molecular interaction maps (MIMs) use a clear, accurate, and versatile graphical language to depict complex biological processes. Here, we discuss the main features of the MIM language and its potential uses. MIMs can be used as database resources and simulation guides, and can serve to generate new hypotheses regarding the roles of specific molecules in the bioregulatory networks that control progression through the cell cycle, differentiation, and cell death.

*Corresponding authors. E-mail: aladjemm{at}mail.nih.gov (M.I.A.); kohnk{at}dc37a.nci.nih.gov (K.W.K).

Citation: M. I. Aladjem, S. Pasa, S. Parodi, J. N. Weinstein, Y. Pommier, K. W. Kohn, Molecular Interaction Maps--A Diagrammatic Graphical Language for Bioregulatory Networks. Sci. STKE 2004, pe8 (2004).

Read the Full Text

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Chromatin Challenges during DNA Replication: A Systems Representation.
K. W. Kohn, M. I. Aladjem, J. N. Weinstein, and Y. Pommier (2008)
Mol. Biol. Cell 19, 1-7
   Abstract »    Full Text »    PDF »
Rules for Modeling Signal-Transduction Systems.
W. S. Hlavacek, J. R. Faeder, M. L. Blinov, R. G. Posner, M. Hucka, and W. Fontana (2006)
Sci. STKE 2006, re6
   Abstract »    Full Text »    PDF »
Phosphorylation of BLM, Dissociation from Topoisomerase III{alpha}, and Colocalization with {gamma}-H2AX after Topoisomerase I-Induced Replication Damage.
V. A. Rao, A. M. Fan, L. Meng, C. F. Doe, P. S. North, I. D. Hickson, and Y. Pommier (2005)
Mol. Cell. Biol. 25, 8925-8937
   Abstract »    Full Text »    PDF »
Electronic Data Sources for Kinetic Models of Cell Signaling.
G. V. HarshaRani, S. J. Vayttaden, and U. S. Bhalla (2005)
J. Biochem. 137, 653-657
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882