Allosteric Modulation of Ion Channels: The Case of Maxi-K

Brad S. Rothberg^*

Department of Physiology, University of Texas Health Science Center, San Antonio, TX 78229, USA.

Summary: Maxi-K channel gating is modulated by both membrane voltage and cytoplasmic Ca²⁺. Recent work has led to a quantitative understanding of this dual regulatory mechanism, derived from classical allosteric principles, in terms of the energetic coupling among membrane voltage, Ca²⁺ binding, and opening of the channel’s gate. Our new understanding of the gating pathway can be applied to the interpretation of mutagenesis experiments and may serve as an example in the analysis of other dually regulated signaling molecules.

*Contact information. E-mail: rothberg{at}uthscsa.edu

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