Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. STKE, 27 July 2004
Vol. 2004, Issue 243, p. pe32
[DOI: 10.1126/stke.2432004pe32]

PERSPECTIVES

Cellular Domains That Contribute to Ca2+ Entry Events

Indu S. Ambudkar*

Secretory Physiology Section, Gene Therapy and Therapeutics Branch (GTTB), National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health, Bethesda, MD 20892, USA.

Abstract: Stimulation of cell surface receptors that increase phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis leads to intracellular Ca2+ release and activation of plasma membrane Ca2+ entry channels. Ca2+ entry via these channels regulates a wide array of physiological functions. The molecular composition of these channels and the mechanisms that activate or inactivate them have not yet been elucidated. Members of the TRPC subfamily of the TRP (transient receptor potential) family of proteins have been recently suggested as molecular components of these channels. In addition, Ca2+ signaling proteins and the signals they generate are compartmentalized and spatiotemporally regulated. Thus, the mechanisms involved in the assembly and trafficking of Ca2+ signaling proteins, including TRPC channels, will determine the regulation of Ca2+ entry and its effect on cellular function.

*Contact information. E-mail: indu.ambudkar{at}nih.gov

Citation: I. S. Ambudkar, Cellular Domains That Contribute to Ca2+ Entry Events. Sci. STKE 2004, pe32 (2004).

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Distant Cytosolic Residues Mediate a Two-way Molecular Switch That Controls the Modulation of Inwardly Rectifying Potassium (Kir) Channels by Cholesterol and Phosphatidylinositol 4,5-Bisphosphate (PI(4,5)P2).
A. Rosenhouse-Dantsker, S. Noskov, H. Han, S. K. Adney, Q.-Y. Tang, A. A. Rodriguez-Menchaca, G. B. Kowalsky, V. I. Petrou, C. V. Osborn, D. E. Logothetis, et al. (2012)
J. Biol. Chem. 287, 40266-40278
   Abstract »    Full Text »    PDF »
Toward a Consensus on the Operation of Receptor-Induced Calcium Entry Signals.
D. L. Gill and R. L. Patterson (2004)
Sci. STKE 2004, pe39
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882