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Sci. STKE, 27 July 2004
Vol. 2004, Issue 243, p. pe38
[DOI: 10.1126/stke.2432004pe38]

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Store-Operated Calcium Entry: A Tough Nut to CRAC

Reinhold Penner* and Andrea Fleig

Laboratory of Cell and Molecular Signaling, Center for Biomedical Research at The Queen’s Medical Center and John A. Burns School of Medicine at the University of Hawaii, Honolulu, HI 96813, USA.

Summary: Store-operated or capacitative Ca2+ entry is a prominent feature of many electrically nonexcitable cell types. It is due to Ca2+ ion permeation pathways in the plasma membrane that are activated after receptor-mediated Ca2+ release from intracellular stores. Despite hundreds of publications on the topic of store-operated Ca2+ entry and intense efforts by many dedicated laboratories, neither the molecular nature of the ion permeation pathway nor its activation mechanism is known. Here we review the progress made on the characterization of store-operated currents and the challenges encountered in identifying the molecular components of store-operated Ca2+ entry.

*Corresponding author. E-mail: rpenner{at}hawaii.edu

Citation: R. Penner, A. Fleig, Store-Operated Calcium Entry: A Tough Nut to CRAC. Sci. STKE 2004, pe38 (2004).

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Toward a Consensus on the Operation of Receptor-Induced Calcium Entry Signals.
D. L. Gill and R. L. Patterson (2004)
Sci. STKE 2004, pe39
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