Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. STKE, 27 July 2004
Vol. 2004, Issue 243, p. pe39
[DOI: 10.1126/stke.2432004pe39]

PERSPECTIVES

Toward a Consensus on the Operation of Receptor-Induced Calcium Entry Signals

Donald L. Gill1* and Randen L. Patterson2*

1Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
2208 Mueller Laboratory, The Pennsylvania State University, University Park, PA 16802, USA.

Abstract: Receptor-induced Ca2+ signals involve both Ca2+ release from intracellular stores and extracellular Ca2+ entry across the plasma membrane. The channels mediating Ca2+ entry and the mechanisms controlling their function remain largely a mystery. Here we critically assess current views on the Ca2+ entry process and consider certain modifications to the widely held hypothesis that Ca2+ store emptying is the fundamental trigger for receptor-induced Ca2+ entry channels. Under physiological conditions, receptor-induced store depletion may be quite limited. A number of distinct channel activities appear to mediate receptor-induced Ca2+ entry, and their activation is observed to occur through quite diverse coupling processes.

*Corresponding authors. E-mail: dgill{at}umaryland.edu (D.L.G); runkinatiaaar{at}aol.com (R.L.P.)

Citation: D. L. Gill, R. L. Patterson, Toward a Consensus on the Operation of Receptor-Induced Calcium Entry Signals. Sci. STKE 2004, pe39 (2004).

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Insulin Secretion and Ca2+ Dynamics in {beta}-Cells Are Regulated by PERK (EIF2AK3) in Concert with Calcineurin.
R. Wang, B. C. McGrath, R. F. Kopp, M. W. Roe, X. Tang, G. Chen, and D. R. Cavener (2013)
J. Biol. Chem. 288, 33824-33836
   Abstract »    Full Text »    PDF »
New molecular players in capacitative Ca2+ entry.
J. W. Putney Jr (2007)
J. Cell Sci. 120, 1959-1965
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882