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Sci. STKE, 12 October 2004
Vol. 2004, Issue 254, p. pe48
[DOI: 10.1126/stke.2542004pe48]

PERSPECTIVES

Expanded Nuclear Roles for I{kappa}Bs

Paul W. Bates and Shigeki Miyamoto*

Department of Pharmacology, University of Wisconsin-Madison Medical School, 301 Service Memorial Institute, 1300 University Avenue, Madison, WI 53706, USA.

Summary: I kappa B (I{kappa}B) was initially identified as a factor that inhibits DNA binding and nuclear translocation of the transcription factor nuclear factor kappa B (NF-{kappa}B). Recently, however, I{kappa}B family members have demonstrated direct nuclear roles in regulating NF-{kappa}B–dependent transcription. Some I{kappa}B proteins, including I{kappa}B{alpha} and I{kappa}Bß, can regulate transcription by modulating the concentration of active NF-{kappa}B complexes within the nucleus. Others, such as I{kappa}B{zeta} and Bcl-3, can directly activate transcription by forming transcriptional complexes at gene promoters. Thus, I{kappa}B proteins play important nuclear roles in regulating NF-{kappa}B–dependent transcription after stimulation with various extracellular signals.

*Corresponding author. Telephone, 608-262-9281; e-mail, smiyamot{at}wisc.edu

Citation: P. W. Bates, S. Miyamoto, Expanded Nuclear Roles for I{kappa}Bs. Sci. STKE 2004, pe48 (2004).

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