Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Agilent Webinar

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Sci. STKE, 22 February 2005
Vol. 2005, Issue 272, p. re3
[DOI: 10.1126/stke.2722005re3]

REVIEWS

The TRP Superfamily of Cation Channels

Craig Montell*

Department of Biological Chemistry, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.

Abstract: The transient receptor potential (TRP) protein superfamily consists of a diverse group of cation channels that bear structural similarities to Drosophila TRP. TRP channels play important roles in nonexcitable cells; however, an emerging theme is that many TRP-related proteins are expressed predominantly in the nervous system and function in sensory physiology. The TRP superfamily is divided into seven subfamilies, the first of which is composed of the "classical" TRPs" (TRPC subfamily). Some TRPCs may be store-operated channels, whereas others appear to be activated by production of diacylglycerol or regulated through an exocytotic mechanism. Many members of a second subfamily (TRPV) function in sensory physiology and respond to heat, changes in osmolarity, odorants, and mechanical stimuli. Two members of the TRPM family function in sensory perception and three TRPM proteins are chanzymes, which contain C-terminal enzyme domains. The fourth and fifth subfamilies, TRPN and TRPA, include proteins with many ankyrin repeats. TRPN proteins function in mechanotransduction, whereas TRPA1 is activated by noxious cold and is also required for the auditory response. In addition to these five closely related TRP subfamilies, which comprise the Group 1 TRPs, members of the two Group 2 TRP subfamilies, TRPP and TRPML, are distantly related to the group 1 TRPs. Mutations in the founding members of these latter subfamilies are responsible for human diseases. Each of the TRP subfamilies are represented by members in worms and flies, providing the potential for using genetic approaches to characterize the normal functions and activation mechanisms of these channels.

* To whom correspondence should be addressed. E-mail: cmontell{at}jhmi.edu

Citation: C. Montell, The TRP Superfamily of Cation Channels. Sci. STKE 2005, re3 (2005).

Read the Full Text

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Hydrolysis of Phosphatidylinositol 4,5-Bisphosphate Mediates Calcium-induced Inactivation of TRPV6 Channels.
B. Thyagarajan, V. Lukacs, and T. Rohacs (2008)
J. Biol. Chem. 283, 14980-14987
   Abstract »    Full Text »    PDF »
Functional Requirement for Orai1 in Store-operated TRPC1-STIM1 Channels.
K. T. Cheng, X. Liu, H. L. Ong, and I. S. Ambudkar (2008)
J. Biol. Chem. 283, 12935-12940
   Abstract »    Full Text »    PDF »
IP3 sensitizes TRPV4 channel to the mechano- and osmotransducing messenger 5'-6'-epoxyeicosatrienoic acid.
J. Fernandes, I. M. Lorenzo, Y. N. Andrade, A. Garcia-Elias, S. A. Serra, J. M. Fernandez-Fernandez, and M. A. Valverde (2008)
J. Cell Biol. 181, 143-155
   Abstract »    Full Text »    PDF »
Effect of increasing temperature on TRPV1-mediated responses in isolated rat pulmonary sensory neurons.
D. Ni and L.-Y. Lee (2008)
Am J Physiol Lung Cell Mol Physiol 294, L563-L571
   Abstract »    Full Text »    PDF »
Development and Validation of a Cell-Based High-Throughput Screening Assay for TRPM2 Channel Modulators.
Y. Song, B. Buelow, A.-L. Perraud, and A. M. Scharenberg (2008)
J Biomol Screen 13, 54-61
   Abstract »    PDF »
A helix-breaking mutation in TRPML3 leads to constitutive activity underlying deafness in the varitint-waddler mouse.
C. Grimm, M. P. Cuajungco, A. F. J. van Aken, M. Schnee, S. Jors, C. J. Kros, A. J. Ricci, and S. Heller (2007)
PNAS 104, 19583-19588
   Abstract »    Full Text »    PDF »
Drosophila TRP channels require a protein with a distinctive motif encoded by the inaF locus.
Y. Cheng and H. A. Nash (2007)
PNAS 104, 17730-17734
   Abstract »    Full Text »    PDF »
Function and dynamics of PKD2 in Chlamydomonas reinhardtii flagella.
K. Huang, D. R. Diener, A. Mitchell, G. J. Pazour, G. B. Witman, and J. L. Rosenbaum (2007)
J. Cell Biol. 179, 501-514
   Abstract »    Full Text »    PDF »
Pharmacological Characterization and Molecular Determinants of the Activation of Transient Receptor Potential V2 Channel Orthologs by 2-Aminoethoxydiphenyl Borate.
V. Juvin, A. Penna, J. Chemin, Y.-L. Lin, and F.-A. Rassendren (2007)
Mol. Pharmacol. 72, 1258-1268
   Abstract »    Full Text »    PDF »
Vasopressin-induced membrane trafficking of TRPC3 and AQP2 channels in cells of the rat renal collecting duct.
M. Goel, W. G. Sinkins, C.-D. Zuo, U. Hopfer, and W. P. Schilling (2007)
Am J Physiol Renal Physiol 293, F1476-F1488
   Abstract »    Full Text »    PDF »
Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1( / ) mice.
X. Liu, K. T. Cheng, B. C. Bandyopadhyay, B. Pani, A. Dietrich, B. C. Paria, W. D. Swaim, D. Beech, E. Yildrim, B. B. Singh, et al. (2007)
PNAS 104, 17542-17547
   Abstract »    Full Text »    PDF »
A Quantitative Structure Activity Analysis on the Relative Sensitivity of the Olfactory and the Nasal Trigeminal Chemosensory Systems.
M. H. Abraham, R. Sanchez-Moreno, J. E. Cometto-Muniz, and W. S. Cain (2007)
Chem Senses 32, 711-719
   Abstract »    Full Text »    PDF »
Modulation of TRPs by PIPs.
T. Voets and B. Nilius (2007)
J. Physiol. 582, 939-944
   Abstract »    Full Text »    PDF »
An integrative approach to understanding mechanosensation.
C. C. Poirier and P. A. Iglesias (2007)
Brief Bioinform 8, 258-265
   Abstract »    Full Text »    PDF »
Inspiratory bursts in the preBotzinger complex depend on a calcium-activated non-specific cation current linked to glutamate receptors in neonatal mice.
R. W. Pace, D. D. Mackay, J. L. Feldman, and C. A. Del Negro (2007)
J. Physiol. 582, 113-125
   Abstract »    Full Text »    PDF »
RCAN1 (DSCR1) increases neuronal susceptibility to oxidative stress: a potential pathogenic process in neurodegeneration.
S. Porta, S. A. Serra, M. Huch, M. A. Valverde, F. Llorens, X. Estivill, M. L. Arbones, and E. Marti (2007)
Hum. Mol. Genet. 16, 1039-1050
   Abstract »    Full Text »    PDF »
Open Channel Block by Ca2+ Underlies the Voltage Dependence of Drosophila TRPL Channel.
M. Parnas, B. Katz, and B. Minke (2007)
J. Gen. Physiol. 129, 17-28
   Abstract »    Full Text »    PDF »
Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange.
N. Weissmann, A. Dietrich, B. Fuchs, H. Kalwa, M. Ay, R. Dumitrascu, A. Olschewski, U. Storch, M. Mederos y Schnitzler, H. A. Ghofrani, et al. (2006)
PNAS 103, 19093-19098
   Abstract »    Full Text »    PDF »
A Phosphoinositide Synthase Required for a Sustained Light Response.
T. Wang and C. Montell (2006)
J. Neurosci. 26, 12816-12825
   Abstract »    Full Text »    PDF »
Receptor-induced Activation of Drosophila TRP{gamma} by Polyunsaturated Fatty Acids.
S. Jors, V. Kazanski, A. Foik, D. Krautwurst, and C. Harteneck (2006)
J. Biol. Chem. 281, 29693-29702
   Abstract »    Full Text »    PDF »
Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor.
Y. Ishimaru, H. Inada, M. Kubota, H. Zhuang, M. Tominaga, and H. Matsunami (2006)
PNAS 103, 12569-12574
   Abstract »    Full Text »    PDF »
Lysosomal Localization of TRPML3 Depends on TRPML2 and the Mucolipidosis-associated Protein TRPML1.
K. Venkatachalam, T. Hofmann, and C. Montell (2006)
J. Biol. Chem. 281, 17517-17527
   Abstract »    Full Text »    PDF »
Pharmacological and Electrophysiological Characterization of Store-Operated Currents and Capacitative Ca2+ Entry in Vascular Smooth Muscle Cells.
L. I. Brueggemann, D. R. Markun, K. K. Henderson, L. L. Cribbs, and K. L. Byron (2006)
J. Pharmacol. Exp. Ther. 317, 488-499
   Abstract »    Full Text »    PDF »
Human TRPC6 expressed in HEK 293 cells forms non-selective cation channels with limited Ca2+ permeability.
M. Estacion, W. G. Sinkins, S. W. Jones, M. A. B. Applegate, and W. P. Schilling (2006)
J. Physiol. 572, 359-377
   Abstract »    Full Text »    PDF »
TRPM2 is an ion channel that modulates hematopoietic cell death through activation of caspases and PARP cleavage.
W. Zhang, I. Hirschler-Laszkiewicz, Q. Tong, K. Conrad, S.-C. Sun, L. Penn, D. L. Barber, R. Stahl, D. J. Carey, J. Y. Cheung, et al. (2006)
Am J Physiol Cell Physiol 290, C1146-C1159
   Abstract »    Full Text »    PDF »
TRP channels in Drosophila photoreceptor cells.
C. Montell (2005)
J. Physiol. 567, 45-51
   Abstract »    Full Text »    PDF »
Functional role of TRPC proteins in native systems: implications from knockout and knock-down studies.
M. Freichel, R. Vennekens, J. Olausson, S. Stolz, S. E Philipp, P. Weissgerber, and V. Flockerzi (2005)
J. Physiol. 567, 59-66
   Abstract »    Full Text »    PDF »
TRP Channels in Disease.
B. Nilius, T. Voets, and J. Peters (2005)
Sci. STKE 2005, re8
   Abstract »    Full Text »    PDF »
Molecular Analysis of a Store-operated and 2-Acetyl-sn-glycerol-sensitive Non-selective Cation Channel: HETEROMERIC ASSEMBLY OF TRPC1-TRPC3.
X. Liu, B. C. Bandyopadhyay, B. B. Singh, K. Groschner, and I. S. Ambudkar (2005)
J. Biol. Chem. 280, 21600-21606
   Abstract »    Full Text »    PDF »
TRP Channels.
T. Rohacs (2005)
Sci. STKE 2005, tr14
   Abstract »    Full Text »    PDF »

ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)