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Sci. STKE, 29 March 2005
Vol. 2005, Issue 277, p. pe13
[DOI: 10.1126/stke.2772005pe13]

PERSPECTIVES

Signaling the Junctions in Gut Epithelium

Frédéric Hollande1, Arthur Shulkes2, and Graham S. Baldwin2*

1Functional Genomics Institute (IGF), Cellular and Molecular Oncology Department, CNRS UMR5203/INSERMU661-UM1-UM2, Montpellier, France.
2University of Melbourne Department of Surgery, Austin Health, Melbourne, Australia.

Summary: This Perspective summarizes recent developments in our understanding of the signaling pathways involved in the regulation of epithelial cell adhesion in the gut. The role of phosphatidylinositol 3-kinase signaling in the modulation of adherens junctions, and the connections between tight junctions and nuclear transcription factors, are discussed. The effect of gastrins on adherens and tight junctions is presented as an example of the regulation of adhesion by growth factors. The consequences of dysregulation of adherens junctions and tight junctions for human pathology are also considered.

*Corresponding author. Telephone, 613-9496-5592; fax, 613-9458-1650; e-mail, grahamsb{at}unimelb.edu.au

Citation: F. Hollande, A. Shulkes, G. S. Baldwin, Signaling the Junctions in Gut Epithelium. Sci. STKE 2005, pe13 (2005).

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