Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 12 April 2005
Vol. 2005, Issue 279, p. tw136
[DOI: 10.1126/stke.2792005tw136]

EDITORS' CHOICE

IMMUNOLOGY Earliest Influences

In the immune system, developing thymocytes depend critically on an intimate association with the organized stromal microenvironment of the thymus, which is made up primarily of thymic epithelial cells. Akiyama et al. demonstrate the importance of this association for T cell tolerance. A deficiency in the RING domain ubiquitin ligase TRAF6 caused a loss of organized thymic epithelial architecture. The severe impairment of T cell development then leads to autoimmunity.

T. Akiyama, S. Maeda, S. Yamane, K. Ogino, M. Kasai, F. Kajiura, M. Matsumoto, J.-I. Inoue, Dependence of self-tolerance on TRAF6-directed development of thymic stroma. Science 308, 248-251 (2005). [Abstract] [Full Text]

Citation: Earliest Influences. Sci. STKE 2005, tw136 (2005).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882