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Sci. STKE, 19 July 2005
Vol. 2005, Issue 293, p. cm9
[DOI: 10.1126/stke.2932005cm9]

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Interleukin-4 (IL-4) Pathway

Ann Kelly-Welch1, Erica M. Hanson2, and Achsah D. Keegan1*

1 Program in Oncology, Marlene and Stewart Greenebaum Cancer Center and Department of Microbiology and Immunology, University of Maryland, Baltimore, USA.
2 Department of Biology, University of Maryland Baltimore County, Catonsville, MD, USA.

Abstract: Interleukin-4 (IL-4) is a cytokine produced by TH2 type helper T cells and by mast cells, basophils, and eosinophils. This cytokine can elicit many responses, some of which are associated with allergy and asthma. Studies with long-term cell lines and primary cells have revealed differences in the signaling between these two experimental systems. Understanding these differences is important because therapeutic strategies targeting IL-4 and its signaling pathways are currently being tested to treat allergy and asthma.

*Corresponding author. E-mail, akeegan{at}som.umaryland.edu

Citation: A. Kelly-Welch, E. M. Hanson, A. D. Keegan, Interleukin-4 (IL-4) Pathway. Sci. STKE 2005, cm9 (2005).

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cutting Edge: IL-4-Mediated Protection of Primary B Lymphocytes from Apoptosis via Stat6-Dependent Regulation of Glycolytic Metabolism.
F. J. Dufort, B. F. Bleiman, M. R. Gumina, D. Blair, D. J. Wagner, M. F. Roberts, Y. Abu-Amer, and T. C. Chiles (2007)
J. Immunol. 179, 4953-4957
   Abstract »    Full Text »    PDF »
IL-4-stimulated NF-{kappa}B activity is required for Stat6 DNA binding.
V. T. Thieu, E. T. Nguyen, B. P. McCarthy, H. A. Bruns, R. Kapur, C.-H. Chang, and M. H. Kaplan (2007)
J. Leukoc. Biol. 82, 370-379
   Abstract »    Full Text »    PDF »

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