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Sci. STKE, 4 October 2005 PERSPECTIVESIntracellular Glucocorticoid Signaling: A Formerly Simple System Turns StochasticGeorge P. Chrousos1,2* and Tomoshige Kino2
1Department of Pediatrics, University of Athens, Athens 115 27, Greece. Summary:
Glucocorticoids contribute fundamentally to the maintenance of basal and stress-related homeostasis in all higher organisms. The major roles of these steroids in physiology are amply matched by their remarkable contributions to pathology. Glucocorticoids influence about 20% of the expressed human genome, and their effects spare almost no organs or tissues. For many years we thought that the numerous actions of glucocorticoids were mediated by a single receptor molecule: the classic glucocorticoid receptor (GR) isoform *Corresponding author. E-mail: chrousge{at}med.uoa.gr
Citation: G. P. Chrousos, T. Kino, Intracellular Glucocorticoid Signaling: A Formerly Simple System Turns Stochastic. Sci. STKE 2005, pe48 (2005). THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)