Regulation of Voltage-Gated Ca2+ Channels by Calmodulin

doi:10.1126/stke.3152005re15

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Sci. STKE, 20 December 2005
Vol. 2005, Issue 315, p. re15
[DOI: 10.1126/stke.3152005re15]

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Regulation of Voltage-Gated Ca²⁺ Channels by Calmodulin

D. Brent Halling, Paula Aracena-Parks, and Susan L. Hamilton^*

Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA.

Abstract: Calmodulin, a highly versatile and ubiquitously expressed Ca²⁺ sensor, regulates the function of many enzymes and ion channels. Both Ca²⁺-dependent inactivation and Ca²⁺-dependent facilitation of the voltage-gated Ca²⁺ channels Cav1.2 and Cav2.1 are regulated through an interaction with Ca²⁺-bound calmodulin. This review addresses the functional regulation of Cav1.2 and Cav2.1 by calmodulin and discusses how Ca²⁺ binding to a single calmodulin molecule can regulate opposing functions of the voltage-gated Ca²⁺ channels.

*Corresponding author. E-mail: susanh{at}bcm.tmc.edu

Citation: D. B. Halling, P. Aracena-Parks, S. L. Hamilton, Regulation of Voltage-Gated Ca²⁺ Channels by Calmodulin. Sci. STKE 2005, re15 (2005).

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