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Sci. STKE, 20 December 2005
Vol. 2005, Issue 315, p. re15
[DOI: 10.1126/stke.3152005re15]
REVIEWS
Regulation of Voltage-Gated Ca2+ Channels by Calmodulin
D. Brent Halling,
Paula Aracena-Parks, and
Susan L. Hamilton*
Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA.
Abstract:
Calmodulin, a highly versatile and ubiquitously expressed Ca2+ sensor, regulates the function of many enzymes and ion channels. Both Ca2+-dependent inactivation and Ca2+-dependent facilitation of the voltage-gated Ca2+ channels Cav1.2 and Cav2.1 are regulated through an interaction with Ca2+-bound calmodulin. This review addresses the functional regulation of Cav1.2 and Cav2.1 by calmodulin and discusses how Ca2+ binding to a single calmodulin molecule can regulate opposing functions of the voltage-gated Ca2+ channels.
Truncation of Murine Cav1.2 at Asp-1904 Results in Heart Failure after Birth.
K. Domes, J. Ding, T. Lemke, A. Blaich, J. W. Wegener, J. Brandmayr, S. Moosmang, and F. Hofmann (2011)
J. Biol. Chem.
286, 33863-33871
|Abstract »|Full Text »|PDF »
Global Gene Expression Analysis of Rodent Motor Neurons Following Spinal Cord Injury Associates Molecular Mechanisms With Development of Postinjury Spasticity.
J. Wienecke, A-C. Westerdahl, H. Hultborn, O. Kiehn, and J. Ryge (2010)
J Neurophysiol
103, 761-778
|Abstract »|Full Text »|PDF »
Calmodulin Is a Functional Regulator of Cav1.4 L-type Ca2+ Channels.
K. Griessmeier, H. Cuny, K. Rotzer, O. Griesbeck, H. Harz, M. Biel, and C. Wahl-Schott (2009)
J. Biol. Chem.
284, 29809-29816
|Abstract »|Full Text »|PDF »
Calmodulin-dependent gating of Cav1.2 calcium channels in the absence of Cav{beta} subunits.
A. Ravindran, Q. Z. Lao, J. B. Harry, P. Abrahimi, E. Kobrinsky, and N. M. Soldatov (2008)
PNAS
105, 8154-8159
|Abstract »|Full Text »|PDF »
Dynamic but not constitutive association of calmodulin with rat TRPV6 channels enables fine tuning of Ca2+-dependent inactivation.
I. Derler, M. Hofbauer, H. Kahr, R. Fritsch, M. Muik, K. Kepplinger, M. E. Hack, S. Moritz, R. Schindl, K. Groschner, et al. (2006)
J. Physiol.
577, 31-44
|Abstract »|Full Text »|PDF »
