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Sci. STKE, 7 February 2006
Vol. 2006, Issue 321, p. pe7
[DOI: 10.1126/stke.3212006pe7]

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Building Signaling Complexes at the Membrane

Wonhwa Cho*

Department of Chemistry (M/C 111), 845 West Taylor Street, University of Illinois at Chicago, Chicago, IL 60607–7061, USA.

Summary: Cell membranes, the plasma membrane in particular, serve as the hub of various cellular signaling networks. In response to receptor activation, many cytosolic proteins are reversibly recruited to membranes to form dynamic signaling complexes. Membranes provide a unique microenvironment in which the formation of signaling complexes can be exquisitely modulated by the fine interplay between protein-protein and lipid-protein interactions.

*Contact information. Telephone, 312-996-4883; fax, 312-996-2183; e-mail, wcho{at}uic.edu

Citation: W. Cho, Building Signaling Complexes at the Membrane. Sci. STKE 2006, pe7 (2006).

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