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Sci. STKE, 7 March 2006
Vol. 2006, Issue 325, p. pe11
[DOI: 10.1126/stke.3252006pe11]

PERSPECTIVES

Neuregulin-1 and Myelination

Greg Lemke*

The Salk Institute, La Jolla, CA 92037, USA.

Summary: The trigger for the process of myelin formation during neural development has long been a mystery. Recent studies suggest that this trigger is the growth factor neuregulin-1, expressed on the surface of axons, which signals through ErbB2 and ErbB3 receptors expressed on the surface of myelin-forming glia.

*Contact information. E-mail, lemke{at}salk.edu

Citation: G. Lemke, Neuregulin-1 and Myelination. Sci. STKE 2006, pe11 (2006).

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