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Sci. STKE, 25 April 2006
Vol. 2006, Issue 332, p. re3
[DOI: 10.1126/stke.3322006re3]

REVIEWS

Reactive Oxygen Species–Mediated Mitochondria-to-Nucleus Signaling: A Key to Aging and Radical-Caused Diseases

Peter Storz*

Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, 4500 San Pablo Road, Jacksonville, FL 32224, USA.

Abstract: Mitochondria-generated reactive oxygen species have been implicated as a common feature that connects aging of organisms and age-related diseases. Efficient elimination of these radicals by antioxidants correlates with increased life span. Understanding how the mitochondrion signals to the nucleus to regulate antioxidant proteins might be a key to aging processes and treatment of human diseases.

*Corresponding author. E-mail: storz.peter{at}mayo.edu

Citation: P. Storz, Reactive Oxygen Species–Mediated Mitochondria-to-Nucleus Signaling: A Key to Aging and Radical-Caused Diseases. Sci. STKE 2006, re3 (2006).

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Molecular bases of progeroid syndromes.
C. L. Navarro, P. Cau, and N. Levy (2006)
Hum. Mol. Genet. 15, R151-R161
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Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)