Focus Issue: Viruses—Miniature Machiavellis of the Signaling World?

Elizabeth M. Adler^*

Associate Editor of Science's STKE, American Association for the Advancement of Science, 1200 New York Avenue, NW, Washington, DC 20005, USA.

Summary: This week’s issue of Science’s STKE, published in conjunction with a Special Issue of Science on virology, describes viral mechanisms for manipulating signaling pathways in the host cell to ensure their own replication and survival. Münter et al. focus on how viruses and other pathogens manipulate tyrosine kinase- and Rho guanosine triphosphatase-mediated pathways; Barry and Früh discuss how viruses manipulate cullin RING ubiquitin ligases to evade host defenses; and Hayward et al. compare mechanisms whereby Epstein-Barr virus (EBV) and Kaposi's sarcoma associated herpesviruses (KSHV) interact with the Wnt and Notch signaling pathways. In a Review in Science, García-Sastre and Biron discuss the interplay between virus offenses and host defenses, focusing on the role of the type I interferons.

*Contact information. E-mail: eadler{at}aaas.org

The editors suggest the following Related Resources on Science sites:

In Science Signaling

REVIEWS
Infectious Disease
Host-Directed Drug Targeting of Factors Hijacked by Pathogens

Anita Schwegmann and Frank Brombacher (22 July 2008)
Sci. Signal. 1 (29), re8. [DOI: 10.1126/scisignal.129re8]
 |  Gloss »  |  Abstract »  |  Full Text »  |  PDF »

EDITORS' CHOICE
Pharmacology
Antibiotics Target Akt

Nancy R. Gough (4 December 2007)
Sci. STKE 2007 (415), tw441. [DOI: 10.1126/stke.4152007tw441]
 |  Abstract »

In Science Magazine

INTRODUCTION TO SPECIAL ISSUE
Paradigms in the Virosphere

Caroline Ash, Stella Hurtley, Marc Lavine, and Stephen Simpson (12 May 2006)
Science 312 (5775), 869. [DOI: 10.1126/science.312.5775.869]
 |  Summary »  |  PDF »