Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Sci. STKE, 26 September 2006
Vol. 2006, Issue 354, p. pe37
[DOI: 10.1126/stke.3542006pe37]

PERSPECTIVES

mRNA Regulation by Puf Domain Proteins

Robin P. Wharton1* and Aneel K. Aggarwal2*

1Howard Hughes Medical Institute and Duke University Medical School Durham, NC 27710, USA.
2Structural Biology Program, Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York, NY 10029, USA.

Abstract: Puf domain proteins bind specific sequences in mRNAs to regulate their translation or stability, or both. Neither the mechanism of their action nor the identities of targeted mRNAs have been well defined. Recent work suggests that Puf proteins generally act by recruiting Pop2, a deadenylation enzyme that is part of a large complex. Recent work from a separate group defines a subset of the Drosophila transcriptome that is bound by the fly Puf protein, Pumilio. Together, these papers substantially increase our understanding of the biology of the Puf family of mRNA regulators.

*Corresponding authors. E-mail, rwharton{at}duke.edu (R.P.W.); Aneel.Aggarwal{at}mssm.edu (A.K.A.)

Citation: R. P. Wharton, A. K. Aggarwal, mRNA Regulation by Puf Domain Proteins. Sci. STKE 2006, pe37 (2006).

Read the Full Text

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Spatially Restricted Translation of the xCR1 mRNA in Xenopus Embryos.
Y. Zhang, K. D. Forinash, J. McGivern, B. Fritz, K. Dorey, and M. D. Sheets (2009)
Mol. Cell. Biol. 29, 3791-3802
   Abstract »    Full Text »    PDF »
Co-occupancy of two Pumilio molecules on a single hunchback NRE.
Y. K. Gupta, T. H. Lee, T. A. Edwards, C. R. Escalante, L. Y. Kadyrova, R. P. Wharton, and A. K. Aggarwal (2009)
RNA 15, 1029-1035
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882