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Sci. STKE, 7 November 2006
Vol. 2006, Issue 360, p. tw383
[DOI: 10.1126/stke.3602006tw383]

EDITORS' CHOICE

Aging A Cool Way to a Long Life

Paula A. Kiberstis

Science, AAAS, Washington, DC 20005, USA

Caloric dietary restriction prolongs life span in a variety of organisms, and in mammals, the resultant lowering of core body temperature has been offered as one potential explanation. Conti et al. generated transgenic mice that overexpress mitochondrial uncoupling protein 2 in hypocretin-producing neurons within the hypothalamus, which lowers core body temperature by about 0.5ºC. In the absence of caloric restriction, the median life span of these "cool mice" was about 15% greater than that of their wild-type littermates.

B. Conti, M. Sanchez-Alavez, R. Winsky-Sommerer, M. C. Morale, J. Lucero, S. Brownell, V. Fabre, S. Huitron-Resendiz, S. Henriksen, E. P. Zorrilla, L. de Lecea, T. Bartfai, Transgenic mice with a reduced core body temperature have an increased life span. Science 314, 825-828 (2006). [Abstract] [Full Text]

C. B. Saper, Life, the universe, and body temperature. Science 314, 773-774 (2006). [Abstract] [Full Text]

Citation: P. A. Kiberstis, A Cool Way to a Long Life. Sci. STKE 2006, tw383 (2006).

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Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)