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Sci. STKE, 16 January 2007
Vol. 2007, Issue 369, p. tw24
[DOI: 10.1126/stke.3692007tw24]

EDITORS' CHOICE

Biochemistry Describing Delicate Interactions

Valda Vinson

Science, AAAS, Washington, DC 20005, USA

Quantifying the affinities of interactions in biological networks, particularly transient ones, remains a challenge. Maerkl and Quake describe a high-throughput microfluidic platform that allows the measurement of transient and low-affinity interactions and characterize the DNA binding energy landscapes for four eukaryotic transcription factors. In two cases, the binding specificities were used to predict which genes the transcription factors would bind and likely regulate.

S. J. Maerkl, S. R. Quake, A systems approach to measuring the binding energy landscapes of transcription factors. Science 315, 233-237 (2007). [Abstract] [Full Text]

Citation: V. Vinson, Describing Delicate Interactions. Sci. STKE 2007, tw24 (2007).

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Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)