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Sci. STKE, 1 May 2007
Vol. 2007, Issue 384, p. pe21
[DOI: 10.1126/stke.3842007pe21]

PERSPECTIVES

CARD-Bcl10-Malt1 Signalosomes: Missing Link to NF-{kappa}B

Elmar Wegener and Daniel Krappmann*

GSF--National Research Center for Environment and Health, Institute of Toxicology, Ingolstädter Landstrasse 1, D-85764 Neuherberg, Germany.

Abstract: CARD11 (CARMA1), Bcl10, and Malt1 are required for nuclear factor NF-{kappa}B activation in response to antigen recognition. Initially, gene disruption experiments in mice pointed to a lymphocyte-specific role for CARD11-Bcl10-Malt1 complexes. However, strong evidence suggesting that conserved Bcl10-Malt1 complexes interact with different CARD scaffolds to connect various receptors in different cell types to NF-{kappa}B signaling has emerged more recently. The CARD10 (CARMA3)–Bcl10-Malt1 signalosome functions as a link between G protein–coupled receptor (GPCR) signaling and proinflammatory NF-{kappa}B activation. Further, Dectin-1–induced antifungal responses to NF-{kappa}B in dendritic cells depend on CARD9-Bcl10-Malt1. These results identify CARD-Bcl10-Malt1 signalosomes as pivotal regulators that link not only innate and adaptive immune responses, but also GPCR signaling, to the canonical NF-{kappa}B pathway.

*Corresponding author. E-mail, Daniel.Krappmann{at}gsf.de

Citation: E. Wegener, D. Krappmann, CARD-Bcl10-Malt1 Signalosomes: Missing Link to NF-{kappa}B. Sci. STKE 2007, pe21 (2007).

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