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Sci. STKE, 22 May 2007
Vol. 2007, Issue 387, p. pe25
Micromanagement During the Innate Immune Response
James E. Dahlberg* and
Department of Biomolecular Chemistry, University of Wisconsin, Madison, WI 53706, USA.
The innate immune response can be initiated by the binding of various pathogen-associated compounds or cytokines to receptors on the surfaces of dendritic cells. These interactions result in the activation of many genes and gene products. Several different pathways converge to raise the abundance of specific microRNAs (miRNAs). In particular, activation of the transcription factors AP-1 and NF-B results in an increase in the amount of miR-155. High levels of this miRNA are associated with several types of cancer. However, the mRNAs that may be targeted by miR-155 in the innate immune response remain to be determined.
Michael Xiang, Nicolai J. Birkbak, Vida Vafaizadeh, Sarah R. Walker, Jennifer E. Yeh, Suhu Liu, Yasmin Kroll, Mark Boldin, Konstantin Taganov, Bernd Groner, Andrea L. Richardson, and David A. Frank (28 January 2014) Sci. Signal.7 (310), ra11.
[DOI: 10.1126/scisignal.2004497] |Editor's Summary »|Abstract »|Full Text »|PDF »|Supplementary Materials »
John F. Foley (26 January 2010) Sci. Signal.3 (106), ec28.
[DOI: 10.1126/scisignal.3106ec28] |Abstract »
John F. Foley (23 October 2007) Sci. STKE2007 (409), tw385.
[DOI: 10.1126/stke.4092007tw385] |Abstract »
Stephen Simpson (1 May 2007) Sci. STKE2007 (384), tw152.
[DOI: 10.1126/stke.3842007tw152] |Abstract »
Guy Riddihough (20 March 2007) Sci. STKE2007 (378), tw97.
[DOI: 10.1126/stke.3782007tw97] |Abstract »
L. Bryan Ray (6 February 2007) Sci. STKE2007 (372), tw46.
[DOI: 10.1126/stke.3722007tw46] |Abstract »
In Science Magazine
To-Ha Thai, Dinis Pedro Calado, Stefano Casola, K. Mark Ansel, Changchun Xiao, Yingzi Xue, Andrew Murphy, David Frendewey, David Valenzuela, Jeffery L. Kutok, Marc Schmidt-Supprian, Nikolaus Rajewsky, George Yancopoulos, Anjana Rao, and Klaus Rajewsky (27 April 2007) Science316 (5824), 604.
[DOI: 10.1126/science.1141229] |Abstract »|Full Text »|PDF »|Supporting Online Material »
Antony Rodriguez, Elena Vigorito, Simon Clare, Madhuri V. Warren, Philippe Couttet, Dalya R. Soond, Stijn van Dongen, Russell J. Grocock, Partha P. Das, Eric A. Miska, David Vetrie, Klaus Okkenhaug, Anton J. Enright, Gordon Dougan, Martin Turner, and Allan Bradley (27 April 2007) Science316 (5824), 608.
[DOI: 10.1126/science.1139253] |Abstract »|Full Text »|PDF »|Supporting Online Material »
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Differential MicroRNA Expression in Experimental Cerebral and Noncerebral Malaria.
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|Abstract »|Full Text »|PDF »