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Sci. STKE, 29 May 2007
Vol. 2007, Issue 388, p. tw191
[DOI: 10.1126/stke.3882007tw191]

EDITORS' CHOICE

Neuroscience Marijuana and Developmental Damage

Peter Stern

Science, AAAS, Cambridge CB2 1LQ, UK

The effects of marijuana are mediated by cannabinoid receptors on neurons in the brain, and a causal relation between marijuana use during pregnancy and permanent cognitive deficits in the offspring has been identified. Berghuis et al. now define the molecular hierarchy that controls marijuana actions within single neurons and show that activation of cannabinoid receptors by their natural ligands controls the establishment of functional connections between neurons in the brain. These findings define the cellular context through which prenatal marijuana use perturbs brain development.

P. Berghuis, A. M. Rajnicek, Y. M. Morozov, R. A. Ross, J. Mulder, G. M. Urbán, K. Monory, G. Marsicano, M. Matteoli, A. Canty, A. J. Irving, I. Katona, Y. Yanagawa, P. Rakic, B. Lutz, K. Mackie, T. Harkany, Hardwiring the brain: Endocannabinoids shape neuronal connectivity. Science 316, 1212-1216 (2007). [Abstract] [Full Text]

Citation: P. Stern, Marijuana and Developmental Damage. Sci. STKE 2007, tw191 (2007).

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Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)